ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Computationally derived anatomic subtypes of behavioral variant frontotemporal dementia show temporal stability and divergent patterns of longitudinal atrophy.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Cytoarchitectonic gradients of laminar degeneration in behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2025Article
- Altered empathy processing in frontotemporal dementia A task-based fMRI study.bioRxiv : the preprint server for biology · 2024Article
- The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.Frontiers in aging neuroscience · 2024Article
- Atrophy in behavioural variant frontotemporal dementia spans multiple large-scale prefrontal and temporal networks.Brain : a journal of neurology · 2023Article
- Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient.Frontiers in neurology · 2023Article
- Disentangling Clinical Profiles of Apathy in Behavioral Variant Frontotemporal Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Computationally derived anatomic subtypes of behavioral variant frontotemporal dementia show temporal stability and divergent patterns of longitudinal atrophy.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Network-based cortical atrophy predicts longitudinal clinical decline in sporadic behavioral variant frontotemporal dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Detecting short-interval longitudinal cortical atrophy in neurodegenerative dementias via cluster scanning: A proof of concept.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionBehavioral variant frontotemporal dementia (bvFTD) can be computationally divided into four distinct anatomic subtypes based on patterns of frontotemporal and subcortical atrophy. To more precisely predict disease trajectories of individual patients, the temporal stability of each subtype must be characterized.
methodsWe investigated the longitudinal stability of the four previously identified anatomic subtypes in 72 bvFTD patients. We also applied a voxel-wise mixed effects model to examine subtype differences in atrophy patterns across multiple timepoints.
resultsOur results demonstrate the stability of the anatomic subtypes at baseline and over time. While they had common salience network atrophy, each subtype showed distinctive baseline and longitudinal atrophy patterns. DISCUSSION: Recognizing these anatomically heterogeneous subtypes and their different patterns of atrophy progression in early bvFTD will improve disease course prediction in individual patients. Longitudinal volumetric predictions based on these anatomic subtypes may be used as a more accurate endpoint in treatment trials.
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