Evidence map›Paper›PMID 34268433›Full record

ReviewAnnals of translational medicine2021

Artificial intelligence in single photon emission computed tomography (SPECT) imaging: a narrative review.

Wenyi Shao, Steven P Rowe, Yong Du

Open access · diamondAbstract readReview
In one paragraph

Review in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Evolving SPECT-CT technology.The British journal of radiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. AI in SPECT Imaging: Opportunities and Challenges.Seminars in nuclear medicine · 2025
    Review
  6. Technological Advances in SPECT and SPECT/CT Imaging.Diagnostics (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wenyi ShaoDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Steven P RoweDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yong DuDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
Optimization and Validation of Improved Quantitative I-123 Brain SPECT ImagingR01NS094227 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DU, YONG · 2016 to 2019
$1.1M
NCI NIH HHS U01 CA140204NINDS NIH HHS R01 NS094227
6 · The paper itself

Abstract

Artificial intelligence (AI) has been widely applied to medical imaging. The use of AI for emission computed tomography, particularly single-photon emission computed tomography (SPECT) emerged nearly 30 years ago but has been accelerated in recent years due to the development of AI technology. In this review, we will describe and discuss the progress of AI technology in SPECT imaging. The applications of AI are dispersed in disease prediction and diagnosis, post-reconstruction image denoising, attenuation map generation, and image reconstruction. These applications are relevant to many disease categories such as the neurological disorders, kidney failure, cancer, heart disease, etc. This review summarizes these applications so that SPECT researchers can have a reference overview of the role of AI in current SPECT studies. For each application, we followed the timeline to present the evolution of AI's usage and offered insights on how AI was combined with the knowledge of underlying physics as well as traditional non-learning techniques. Ultimately, AI applications are critical to the progress of modern SPECT technology because they provide compensations for many deficiencies in conventional SPECT imaging methods and demonstrate unparalleled success. Nonetheless, AI also has its own challenges and limitations in the medical field, including SPECT imaging. These fundamental questions are discussed, and possible future directions and countermeasures are suggested.

Indexed as

Artificial intelligence (AI)deep learningmachine learningneural networksingle-photon emission computed tomography (SPECT)

Identifiers

PMID34268433
PMCPMC8246162
OpenAlexW3138774998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.