Evidence map›Paper›PMID 34268396›Full record

ArticleAnnals of translational medicine2021

Effect of spontaneous breathing on ventilator-free days in critically ill patients-an analysis of patients in a large observational cohort.

Aline Mela Dos Reis, Thais Dias Midega, Rodrigo Octavio Deliberato, Alistair Ew Johnson, Lucas Bulgarelli, Thiago Domingos Correa, Leo Anthony Celi, Paolo Pelosi, Marcelo Gama De Abreu, Marcus J Schultz and 1 more

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In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 8 countries.

Aline Mela Dos ReisDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Thais Dias MidegaDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Rodrigo Octavio DeliberatoDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Alistair Ew JohnsonLaboratory for Computational Physiology, Institute for Medical Engineering & Science, MIT, Cambridge, MA, USA.
Lucas BulgarelliBig Data Analytics Group, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Thiago Domingos CorreaDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Leo Anthony CeliLaboratory for Computational Physiology, Institute for Medical Engineering & Science, MIT, Cambridge, MA, USA.
Paolo PelosiIRCCS San Martino Policlinico Hospital, Genoa, Italy.
Marcelo Gama De AbreuPulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Marcus J SchultzDepartment of Intensive Care & 'Laboratory of Experimental Intensive Care and Anesthesiology' (L·E·I·C·A), Academic Medical Center, Amsterdam, The Netherlands.
Ary Serpa NetoDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Hospital Israelita Albert Einstein · BRBeth Israel Deaconess Medical Center · USMahidol University · THOspedale Policlinico San Martino · ITThe University of Melbourne · AU

Funding

Critical Care Informatics: Ethical considerations around the use and sharing of health-related dataR01EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, MARK, ROGER GREENWOOD · 2014 to 2021
$3.8M
NIBIB NIH HHS R01 EB017205
6 · The paper itself

Abstract

backgroundMechanical ventilation can injure lung tissue and respiratory muscles. The aim of the present study is to assess the effect of the amount of spontaneous breathing during mechanical ventilation on patient outcomes.

methodsThis is an analysis of the database of the 'Medical Information Mart for Intensive Care (MIMIC)'-III, considering intensive care units (ICUs) of the Beth Israel Deaconess Medical Center (BIDMC), Boston, MA. Adult patients who received invasive ventilation for at least 48 hours were included. Patients were categorized according to the amount of spontaneous breathing, i.e., ≥50% ('high spontaneous breathing') and <50% ('low spontaneous breathing') of time during first 48 hours of ventilation. The primary outcome was the number of ventilator-free days.

resultsIn total, the analysis included 3,380 patients; 70.2% were classified as 'high spontaneous breathing', and 29.8% as 'low spontaneous breathing'. Patients in the 'high spontaneous breathing' group were older, had more comorbidities, and lower severity scores. In adjusted analysis, the amount of spontaneous breathing was not associated with the number of ventilator-free days [20.0 (0.0-24.2)

conclusionsIn patients surviving and receiving ventilation for at least 48 hours, the amount of spontaneous breathing during this period was not associated with an increased number of ventilator-free days.

Indexed as

acute respiratory distress syndrome (ARDS)Mechanical ventilationpositive end-expiratory pressure (PEEP)spontaneous breathingtidal volumeventilator-induced lung injury

Identifiers

PMID34268396
PMCPMC8246163
OpenAlexW3157942339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.