ArticleAnnals of translational medicine2021
Leukocyte subtypes and adverse clinical outcomes in patients with acute ischemic cerebrovascular events.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Predictive value of preoperative and postoperative controlling nutritional status scores and their changes in older patients with large vessel occlusion stroke after endovascular thrombectomy.Frontiers in nutrition · 2026Article
- Leucocytosis and outcomes in older ICU patients after ischaemic stroke: a binational multicentre cohort study.BMJ neurology open · 2026Article
- Treatment-Specific Risk Scales for Identifying High-Risk Patients With Poor Prognosis in Acute Ischemic Stroke: A Cohort Study From the National Neurological Medical Center of China.CNS neuroscience & therapeutics · 2025Article
- Plasma Soluble Angiotensin-Converting Enzyme 2 and Risk of Recurrent Stroke: A Nested Case-Control Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Development and validation of a web-based dynamic nomogram to predict individualized risk of severe carotid artery stenosis based on digital subtract angiography.Frontiers in neurology · 2025Article
- Prognostic value of albumin-based malnutritional indices on short-term outcome in acute ischemic stroke patients undergoing reperfusion therapy.Frontiers in nutrition · 2025Article
- Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis.Frontiers in aging neuroscience · 2025Article
- Evaluation of Hemoglobin and Eosinophil Count in Patients Receiving Thrombolytic Treatment.Cureus · 2024Article
- Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke.Cell communication and signaling : CCS · 2024Article
- Monocyte to high-density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack.CNS neuroscience & therapeutics · 2023Article
- Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke.BMC medicine · 2023Article
- Elevated white blood cell counts in ischemic stroke patients are associated with increased mortality and new vascular events.Frontiers in neurology · 2023Article
- Article
- Baseline Objective Malnutritional Indices as Immune-Nutritional Predictors of Long-Term Recurrence in Patients with Acute Ischemic Stroke.Nutrients · 2022Article
- Day 1 neutrophil-to-lymphocyte ratio (NLR) predicts stroke outcome after intravenous thrombolysis and mechanical thrombectomy.Frontiers in neurology · 2022Article
- Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur study aimed to evaluate whether the effects on adverse clinical outcomes, defined as death, recurrent stroke, and poor functional outcomes, differed by leukocyte subtype in patients with acute ischemic cerebrovascular events, including both ischemic stroke and transient ischemic attack (TIA).
methodsWe derived data from the Third China National Stroke Registry (CNSR-III). The counts and percentages of each leukocyte subtype were collected within the first 24 hours after admission. Enrolled patients were classified into four groups by the quartiles of each leukocyte subtype count or percentage. Hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence intervals (CIs) of adverse clinical outcomes were calculated, with the lowest quartile group as the reference category. We used C statistics, integrated discrimination improvement (IDI), and the net reclassification index (NRI) to evaluate each leukocyte subtype's incremental predictive value beyond conventional risk factors.
resultsA total of 14,174 patients were enrolled. Higher counts of leukocytes, neutrophils, and monocytes were associated with elevated risks of adverse clinical outcomes. In contrast, higher counts of lymphocytes and eosinophils were related to reduced risks of adverse clinical outcomes. Meanwhile, basophil counts seemed to not correlate with adverse clinical outcomes. Furthermore, there were also significant associations between the percentages of leukocyte subtypes and adverse clinical outcomes.
conclusionsLeukocyte subtypes had different relationships with adverse clinical outcomes at 3-month and 1-year follow-up in patients with acute ischemic cerebrovascular events and could slightly increase the predictive value compared with the conventional model.
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