Evidence map›Paper›PMID 34268334›Full record

ReviewFrontiers in molecular biosciences2021

Selective Nutrient Transport in Bacteria: Multicomponent Transporter Systems Reign Supreme.

James S Davies, Michael J Currie, Joshua D Wright, Michael C Newton-Vesty, Rachel A North, Peter D Mace, Jane R Allison, Renwick C J Dobson

Abstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Optimizing Stability in Dynamic Small-Molecule Binding Proteins.Journal of the American Chemical Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. AApplied and environmental microbiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Microbial membrane transport proteins and their biotechnological applications.World journal of microbiology & biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James S DaviesBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Michael J CurrieBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Joshua D WrightBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Michael C Newton-VestyBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Rachel A NorthDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Peter D MaceBiochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Jane R AllisonMaurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, Digital Life Institute, University of Auckland, Auckland, New Zealand.
Renwick C J DobsonBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multicomponent transporters are used by bacteria to transport a wide range of nutrients. These systems use a substrate-binding protein to bind the nutrient with high affinity and then deliver it to a membrane-bound transporter for uptake. Nutrient uptake pathways are linked to the colonisation potential and pathogenicity of bacteria in humans and may be candidates for antimicrobial targeting. Here we review current research into bacterial multicomponent transport systems, with an emphasis on the interaction at the membrane, as well as new perspectives on the role of lipids and higher oligomers in these complex systems.

Indexed as

ABC transportermembrane proteinsprotein-protein interactiontransport mechanismTRAP transporter

Identifiers

PMID34268334
PMCPMC8276074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.