Evidence map›Paper›PMID 34268085›Full record

ArticleGland surgery2021

Mammography breast density: an effective supplemental modality for the precise grading of ultrasound BI-RADS 4 categories.

Wei-Min Li, Qiu-Wei Sun, Xiao-Fang Fan, Jun-Chao Zhang, Ting Xu, Qi-Qi Shen, Lei Jia

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In one paragraph

Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wei-Min LiDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.
Qiu-Wei SunDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.
Xiao-Fang FanDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.
Jun-Chao ZhangDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.
Ting XuDepartment of Clinical and Research, Shenzhen Mindray Biomedical Electronics Co., Ltd, Shenzhen, China.
Qi-Qi ShenDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.
Lei JiaDepartment of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh breast density is significantly associated with an increased risk of breast diseases. Presently, suspected breast masses assessed as Breast Imaging-Reporting and Data System (BI-RADS) grade 4 provide a wide range of positive predictive values. Moreover, subcategories (4a, 4b, and 4c) are still under consideration as the diagnostic criteria are neither comprehensive nor objective. However, whether mammography breast density (MBD) has any impact on the accurate grading of BI-RADS 4 assessed by ultrasound (US) remains unknown.

methodsA total of 1,086 women with 1,293 breast masses were included and assessed as BI-RADS 3-5 by US. The subcategories of MBD (from the ACR-a to the ACR-d group) were assessed by mammography according to the criteria of the American College of Radiology (ACR). The clinicopathological characteristics of these patients were reviewed retrospectively. The malignancy rates of breast masses among different subgroups assessed by BI-RADS were re-estimated with MBD.

resultsAlmost all BI-RADS 3 masses were classified as benign and nearly all BI-RADS 5 masses were identified as malignant. Significant inverse associations between MBD and malignancy rates were detected between the BI-RADS 4a and BI-RADS 4b groups. Moreover, malignancy rates decreased significantly from ACR-a to ACR-d for BI-RADS 4a and 4b breast lesions (P<0.001). However, this trend was not observed in BI-RADS 4c breast lesions.

conclusionsMBD could serve as a crucial factor for the accurate grading of BI-RADS 4 lesions assessed by US. We strongly recommend the adoption of the MBD as a possible supplemental screening modality for US. Furthermore, it is equally beneficial for accurate risk assessment and screening recommendations based on MBD.

Indexed as

BI-RADS 4Mammographic breast density (MBD)ultrasound (US)

Identifiers

PMID34268085
PMCPMC8258872

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