Evidence map›Paper›PMID 34267846›Full record

ArticleJournal of hematology2021

Does ABO Blood Groups Affect Outcomes in Hospitalized COVID-19 Patients?

Gagan Kumar, Rahul Nanchal, Martin Hererra, Ankit Sakhuja, Dhaval Patel, Mark Meersman, Drew Dalton, Achuta Kumar Guddati

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Article in Journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gagan KumarDepartment of Pulmonary and Critical Care, Northeast Georgia Health System, Gainesville, GA 30501, USA.
Rahul NanchalDivision of Pulmonary and Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Martin HererraDepartment of Internal Medicine, Northeast Georgia Health System, Gainesville, GA 30501, USA.
Ankit SakhujaDivision of Cardiovascular Critical Care, Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WV 26506, USA.
Dhaval PatelDepartment of Pulmonary and Critical Care, Northeast Georgia Health System, Gainesville, GA 30501, USA.
Mark MeersmanIPC Global, Atlanta, GA 30005, USA.
Drew DaltonIPC Global, Atlanta, GA 30005, USA.
Achuta Kumar GuddatiDivision of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, GA 30909, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlood group type A has been associated with increased susceptibility for coronavirus disease 2019 (COVID-19) infection when compared to group O. The aim of our study was to examine outcomes in hospitalized COVID-19 patients among blood groups A and O.

methodsThis is an observational study. Kruskal-Wallis and Chi-square tests were used to compare continuous and categorical variables. Multivariable logistic regression models were used to examine association of blood groups with rates of mortality and severity of disease. All adult patients (> 18 years) admitted with COVID-19 infection between March 1, 2020 and March 10, 2021 at a large community hospital in Northeast Georgia were included. We compared mortality, severity of disease (use of mechanical ventilation, vasopressor, and acute renal failure), rates of venous thromboembolism and inflammatory markers between the blood groups. We used multivariable logistic regression model to adjust for demographical and clinical characteristics, use of COVID-19 medications and severity.

resultsA total of 3,563 of 5,204 admitted patients had information on blood groups. Of these, 1,301 (36.5%) were group A, 377 (10.6 %) were group B, 133 (3.7%) were group AB and 1,752 (49.2%) were group O. On adjusted analysis, there were no significant differences in rates of intensive care unit (ICU) admissions, mechanical ventilation, vasopressors, acute renal failure, venous thromboembolism and readmission rate between the blood groups A and O. In-hospital mortality was also not statistically different among the blood groups A and O (17.5% vs. 20.1%; P = 0.07). On adjusted analysis, in-hospital mortality was not lower in blood groups O (odds ratio (OR): 1.06; 95% confidence interval (CI): 0.80 - 1.40, P = 0.70).

conclusionsOnce hospitalized with COVID-19 infection, blood groups A and O are not associated with increased severity or in-hospital mortality.

Indexed as

ABO blood groupCOVID-19In-hospital mortality

Identifiers

PMID34267846
PMCPMC8256919

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