ArticlePapers in physics2014
Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations.
Article in Papers in physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Simplifications and approximations in a single-gene circuit modeling.Scientific reports · 2024Article
- Self-consistent theory of transcriptional control in complex regulatory architectures.PloS one · 2017Article
- Promoters Architecture-Based Mechanism for Noise-Induced Oscillations in a Single-Gene Circuit.PloS one · 2016Article
- Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the number of bound repressors affects transcription rate. Effective Hill exponents of the resulting regulatory functions reveal an increase in the nonlinearity of the feedback with the number of binding sites. We identify optimal configurations that maximize the nonlinearity of the feedback. We use a generic model of a biochemical oscillator to show that this increased nonlinearity is reflected in enhanced oscillations, with larger amplitudes over wider oscillatory ranges. Although the study is motivated by genetic oscillations in the zebrafish segmentation clock, our findings may reveal a general principle for gene regulation.
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Registered trials
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