Evidence map›Paper›PMID 34267794›Full record

ArticleNano today2021

Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy.

Masoud Delfi, Rossella Sartorius, Milad Ashrafizadeh, Esmaeel Sharifi, Yapei Zhang, Piergiuseppe De Berardinis, Ali Zarrabi, Rajender S Varma, Franklin R Tay, Bryan Ronain Smith and 1 more

Abstract read
In one paragraph

Article in Nano today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Ferritin Fused with MiniSOG forACS applied bio materials · 2025
    Article
  11. Nanocarriers for cutting-edge cancer immunotherapies.Journal of translational medicine · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masoud DelfiDepartment of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia, Naples 80126, Italy.
Rossella SartoriusInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Naples 80131, Italy.
Milad AshrafizadehFaculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey.
Esmaeel SharifiDepartment of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, 6517838736, Hamadan, Iran.
Yapei ZhangDepartment of Biomedical Engineering, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI 48824, USA.
Piergiuseppe De BerardinisInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Naples 80131, Italy.
Ali ZarrabiSabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey.
Rajender S VarmaRegional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.
Franklin R TayThe Graduate School, Augusta University, Augusta, GA 30912, USA.
Bryan Ronain SmithDepartment of Biomedical Engineering, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI 48824, USA.
Pooyan MakvandiIstituto Italiano di Tecnologia, Centre for Micro-BioRobotics, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.

Funding

Macrophage-specific nanotherapy for breast cancerR01CA244491 · NCI · OHIO STATE UNIVERSITY · PI Bryan Ronain Smith · 2020 to 2026
$2.5M
American Heart Association-American Stroke Association 18TPA34230113NCI NIH HHS R01 CA244491
6 · The paper itself

Abstract

Self-assembled peptides and proteins possess tremendous potential as targeted drug delivery systems and key applications of these well-defined nanostructures reside in anti-cancer therapy. Peptides and proteins can self-assemble into nanostructures of diverse sizes and shapes in response to changing environmental conditions such as pH, temperature, ionic strength, as well as host and guest molecular interactions; their countless benefits include good biocompatibility and high loading capacity for hydrophobic and hydrophilic drugs. These self-assembled nanomaterials can be adorned with functional moieties to specifically target tumor cells. Stimuli-responsive features can also be incorporated with respect to the tumor microenvironment. This review sheds light on the growing interest in self-assembled peptides and proteins and their burgeoning applications in cancer treatment and immunotherapy.

Indexed as

Cancer therapyDrug deliveryImmunotherapySelf-assembled peptides and proteinsStimuli-responsiveVirus-like particles

Identifiers

PMID34267794
PMCPMC8276870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.