ArticleFrontiers in immunology2021
Impact of Sex Differences on Mortality in Patients With Sepsis After Trauma: A Nationwide Cohort Study.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Association of lactate dehydrogenase to albumin ratio with new-onset acute respiratory distress syndrome and all-cause mortality in patients with sepsis: a retrospective cohort study based on the MIMIC-IV database.BMC infectious diseases · 2026Article
- Effects of Lactate on Improving Cognitive Function and Survival Rate in a Mouse Model of Post-Sepsis Cognitive Impairment.Actas espanolas de psiquiatria · 2026Article
- BMI is independently associated with ARDS, sepsis and multiorgan failure after major trauma-results of a high-volume retrospective observational cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Observational
- Association of lactate-to-albumin ratio with 28-day mortality in elderly sepsis patients: a retrospective MIMIC-IV database analysis.BMC infectious diseases · 2026Article
- Do Obesity Classifications Create the Obesity Paradox? A Scoping Review of Obesity Definitions Applied in Sepsis Research.Clinical obesity · 2026Article
- High Mortality and Medical Costs in Geriatric Trauma Patients: Surgical Treatment and Risk Factors from a Retrospective Cohort Study at a Level I Trauma Center.Annals of geriatric medicine and research · 2025Article
- Predicting ICU Mortality Among Septic Patients Using Machine Learning Technique.Journal of clinical medicine · 2025Article
- Alcohol drinking leads to sex-dependent differentiation of T cells.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- Article
- [Urosepsis: pathophysiology, diagnosis, and management-an update].Urologie (Heidelberg, Germany) · 2024Review
- Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis.Intensive care medicine experimental · 2024Article
- The influence of gender on the epidemiology of and outcome from sepsis associated acute kidney injury in ICU: a retrospective propensity-matched cohort study.European journal of medical research · 2024Article
- Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response?Frontiers in immunology · 2024Review
- Fibrinogen Fragment X Mediates Endothelial Barrier Disruption via Suppression of VE-Cadherin.The Journal of surgical research · 2024Article
- Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood.International journal of molecular sciences · 2023Article
- Sex-Related Mortality After Burns: A Scoping Review in the Sadc-Region.Annals of burns and fire disasters · 2023Article
- Sex differences in cardiovascular response to sepsis.American journal of physiology. Cell physiology · 2023Review
- Estrogen receptor subtype mediated anti-inflammation and vasorelaxationFrontiers in endocrinology · 2023Article
- Factors Associated with an Increase in On-Site Time of Pediatric Trauma Patients in a Prehospital Setting: A Nationwide Observational Study in Japan.Children (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Objective: Sepsis is the leading cause of death in intensive care units, and sepsis after trauma is associated with increased mortality rates. However, the characteristics of sepsis after trauma remain unknown, and the influence of sex on mortality remains controversial. This study aimed to assess the role of sex in in-hospital mortality in patients with sepsis after trauma. Methods: We performed a retrospective cohort study involving several emergency hospitals (n=288) in Japan. The data of patients with trauma who developed sepsis after admission from 2004 to 2019 were obtained from the Japan Trauma Data Bank. We divided the patients into two groups according to sex and compared their in-hospital mortality. We also performed subgroup analysis limited to the elderly population (age ≥ 65 years) and evaluated in-hospital mortality between men and women. Results: A total of 1935 patients met the inclusion criteria during the study period. Of these, 1204 (62.2%) were allocated to the male group and 731 (37.8%) to the female group. Multivariable Cox proportional-hazards analysis showed a significantly lower risk of in-hospital mortality in the female group than in the male group (hazard ratio (HR): 0.74, 95% confidence interval (CI): 0.62-0.89; p=0.001). In the subgroup analysis, multivariable Cox proportional hazards still showed significantly lower risks of in-hospital mortality in the female group than in the male group (HR: 0.72, 95% CI: 0.58-0.88; p=0.002). Conclusion: The present study shows a significantly increased survival in the female group when compared to that in the male group of patients with sepsis after trauma. The underlying mechanism remains unclear, and further investigations are required.
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