Evidence map›Paper›PMID 34267689›Full record

ArticleFrontiers in psychiatry2021

An Exploratory Analysis of the Association Between Catechol-O-Methyltransferase and Response to a Randomized Open-Label Placebo Treatment for Cancer-Related Fatigue.

Teri W Hoenemeyer, Navneet Kaur Baidwan, Kathryn Hall, Ted J Kaptchuk, Kevin R Fontaine, Tapan S Mehta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Predictive biomarkers of placebo response in patients with cancer: an exploratory analysis of the ABCD randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  2. Trial
  3. Trial
  4. Placebo treatments for cancer related fatigue: a reply to Jacobs et al. 2026.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. Hacking the Predictive Mind.Entropy (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Teri W HoenemeyerComprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, United States.
Navneet Kaur BaidwanComprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, United States.
Kathryn HallDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Ted J KaptchukProgram of Placebo Studies and the Therapeutic Encounter, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Kevin R FontaineDepartment of Health Behavior, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Tapan S MehtaDepartment of Health Services Administration, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

Efficacy of Open-Label Placebo, Double-Blind Placebo, and Peppermint Oil in IBSR01AT008573 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAPTCHUK, TED, LEMBO, ANTHONY J · 2015 to 2019
$4.3M
Mentoring and Research in Placebo Studies, Asian Medicine, and CAMK24AT004095 · NCCIH · HARVARD MEDICAL SCHOOL · PI KAPTCHUK, TED · 2007 to 2016
$1.4M
NCCIH NIH HHS K24 AT004095NCCIH NIH HHS R01 AT008573
6 · The paper itself

Abstract

Previous studies have identified catechol-O-methyltransferase (COMT), as a key enzyme influencing sympathetic function. Although the

Indexed as

cancer related fatigueCOMT (rs 4680)COMT rs4818 polymorphismnon-deceptive placeboplacebo effect

Identifiers

PMID34267689
PMCPMC8275998
OpenAlexW3174230365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.