Evidence map›Paper›PMID 34267649›Full record

ArticleFrontiers in aging neuroscience2021

Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study.

Mariantonietta Pisaturo, Federica Calò, Antonio Russo, Clarissa Camaioni, Agnese Giaccone, Biagio Pinchera, Ivan Gentile, Filomena Simeone, Angelo Iodice, Paolo Maggi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Factors Associated With Shifts in Caregiving During COVID-19.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mariantonietta PisaturoInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Federica CalòInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Antonio RussoInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Clarissa CamaioniInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Agnese GiacconeInfectious Diseases Unit, Federico II University, Naples, Italy.
Biagio PincheraInfectious Diseases Unit, Federico II University, Naples, Italy.
Ivan GentileInfectious Diseases Unit, Federico II University, Naples, Italy.
Filomena SimeoneInfectious Disease Unit, AORN Caserta, Caserta, Italy.
Angelo IodiceInfectious Disease Unit, AORN Caserta, Caserta, Italy.
Paolo MaggiInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Nicola CoppolaInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia. PATIENTS AND

methodsIn a multicenter, observational, 1:2 matched case-control study all 23 patients with a history of dementia, hospitalized with a diagnosis of SARS-CoV-2 infection from February 28th 2020 to January 31st 2021 were enrolled. For each Case, 2 patients without dementia observed in the same period study, pair matched for gender, age (±5 years), PaO

resultsThe majority of patients were males (60.9% of Cases and Controls) and very elderly [median age 82 years (IQR: 75.5-85) in the Cases and 80 (IQR: 75.5-83.75) in the Controls]. The prevalence of co-pathologies was very high: all the Cases and 43 (93.5%) Controls showed a Charlson comorbidity index of at least 2. During hospitalization the patients in the Case group less frequently had a moderate disease of COVID-19 (35 vs. 67.4%,

conclusionPatients with dementia are vulnerable and have an increased risk of a severe disease and death when infected with COVID-19.

Indexed as

COVID-19deathdementiaSARS-CoV-2severity

Identifiers

PMID34267649
PMCPMC8276052
OpenAlexW3174244400

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.