ReviewInternational journal of nephrology and renovascular disease2021
Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges.
Review in International journal of nephrology and renovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prognostic factors in malaria patients with acute kidney injury: a systematic review and meta analysis.Renal failure · 2026Pooled it
- Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.Malaria journal · 2026Pooled it
- Risk factors for acute kidney injury at presentation among children with CNS malaria: a case control study.Malaria journal · 2022Trial
- Integrating Bulk and Single-Cell RNA Sequencing Identifies and Validates Lactylation-Related Signatures in Acute Kidney Injury.Biomedicines · 2026Article
- Comparison of Kirpa Kit™ manual hemodialysis device to standard continuous kidney replacement therapy in vitro.Pediatric nephrology (Berlin, Germany) · 2026Article
- Acute acalculous cholecystitis and blackwater fever with acute kidney injury in children with malaria: case series and literature review.Malaria journal · 2026Review
- Article
- Malaria-Associated Acute Kidney Injury: A Key Driver of Mortality in Endemic Regions.International journal of nephrology and renovascular disease · 2026Review
- Identification of acute kidney injury in African children with severe malaria: a multinational individual participant data meta-analysis.Research square · 2025Article
- Effect of corticosteroids on haemoglobinuria resolution among children with blackwater fever at Soroti regional referral hospital, Uganda: a retrospective cohort study.Malaria journal · 2025Article
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
- Manual Single-Lumen Alternating Microbatch Dialysis to Deplete Stored Blood Potassium: A Potential Use for Children with Severe Malaria-Associated Acute Kidney Injury.The American journal of tropical medicine and hygiene · 2025Article
- Animal Models of Malaria-Associated Acute Kidney Injury.Seminars in nephrology · 2025Review
- Plasma Neutrophil Gelatinase-Associated Lipocalin as a Biomarker of Kidney Injury and Potential Predictor of Hypoxic Brain Injury in Severe Plasmodium falciparum Malaria: Insights From India.Seminars in nephrology · 2025Review
- Malaria.The New England journal of medicine · 2025Review
- Cytomegalovirus reactivation and acute and chronic complications in children with cerebral malaria: a prospective cohort study.Malaria journal · 2025Article
- Prevalence of asymptomatic malaria infection and associated risk factors in Mizan-Aman town, Ethiopia: community-based cross-sectional study.Malaria journal · 2025Article
- Clinical, immune and genetic risk factors of malaria-associated acute kidney injury in Zambian children: A study protocol.PloS one · 2025Observational
- High water turnover, hydration status, and heat stress among Daasanach pastoralists in a hot, semi-arid climate.Evolution, medicine, and public health · 2025Article
- CD8Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance associated with substantial morbidity and mortality in African children with severe malaria. Using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria to define AKI, an estimated 24-59% of African children with severe malaria have AKI with most AKI community-acquired. AKI is a risk factor for mortality in pediatric severe malaria with a stepwise increase in mortality across AKI stages. AKI is also a risk factor for post-discharge mortality and is associated with increased long-term risk of neurocognitive impairment and behavioral problems in survivors. Following injury, the kidney undergoes a process of recovery and repair. AKI is an established risk factor for chronic kidney disease and hypertension in survivors and is associated with an increased risk of chronic kidney disease in severe malaria survivors. The magnitude of the risk and contribution of malaria-associated AKI to chronic kidney disease in malaria-endemic areas remains undetermined. Pathways associated with AKI pathogenesis in the context of pediatric severe malaria are not well understood, but there is emerging evidence that immune activation, endothelial dysfunction, and hemolysis-mediated oxidative stress all directly contribute to kidney injury. In this review, we outline the KDIGO bundle of care and highlight how this could be applied in the context of severe malaria to improve kidney perfusion, reduce AKI progression, and improve survival. With increased recognition that AKI in severe malaria is associated with substantial post-discharge morbidity and long-term risk of chronic kidney disease, there is a need to increase AKI recognition through enhanced access to creatinine-based and next-generation biomarker diagnostics. Long-term studies to assess severe malaria-associated AKI's impact on long-term health in malaria-endemic areas are urgently needed.
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