ArticleNature neuroscience2021
The basal ganglia control the detailed kinematics of learned motor skills.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
- Transcranial direct current stimulation enhances delayed retention after 5 days of lower-limb motor skill learning.The Journal of physiology · 2026Trial
- Abstract Representation of Movement Parameters in Basal Ganglia Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice.Nature neuroscience · 2026Article
- Replay of procedural memory is independent of the hippocampus.Nature neuroscience · 2026Article
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-Spiking Interneurons by Chronic Alcohol Exposure.Biological psychiatry · 2026Article
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- Early skill learning is shaped by the offline emergence of expert synergies.Current biology : CB · 2026Article
- Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.Psychopharmacology · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape.Aging cell · 2026Article
- Article
- Basal ganglia output dynamically controls skilled forelimb kinematics in real time.bioRxiv : the preprint server for biology · 2026Article
- Engram Synapses and Synapse Dynamics in Memory Processing.Journal of neurochemistry · 2026Review
- Expert Motor Synergies Emerge Predominantly Offline During Early Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical binding of cognition to action in the human basal ganglia-thalamic circuit.bioRxiv : the preprint server for biology · 2026Article
- Neural and motor mechanisms of handwriting: from healthy aging to neurodegenerative disorders.Frontiers in aging neuroscience · 2026Review
- Complementary cortical and striatal encoding of locomotor preparation and performance.iScience · 2025Article
- Reward-driven adaptation of movements requires strong recurrent basal ganglia-cortical loops.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Striatal ensembles specify and control granular forelimb actions.bioRxiv : the preprint server for biology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The basal ganglia are known to influence action selection and modulation of movement vigor, but whether and how they contribute to specifying the kinematics of learned motor skills is not understood. Here, we probe this question by recording and manipulating basal ganglia activity in rats trained to generate complex task-specific movement patterns with rich kinematic structure. We find that the sensorimotor arm of the basal ganglia circuit is crucial for generating the detailed movement patterns underlying the acquired motor skills. Furthermore, the neural representations in the striatum, and the control function they subserve, do not depend on inputs from the motor cortex. Taken together, these results extend our understanding of the basal ganglia by showing that they can specify and control the fine-grained details of learned motor skills through their interactions with lower-level motor circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.