Evidence map›Paper›PMID 34267333›Full record

ReviewProstate cancer and prostatic diseases2022

The microbiome and prostate cancer.

Juan Javier-DesLoges, Rana R McKay, Austin D Swafford, Gregory D Sepich-Poore, Rob Knight, J Kellogg Parsons

Open access · greenAbstract readReview
In one paragraph

Review in Prostate cancer and prostatic diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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  20. Prostate Cancer and the Mevalonate Pathway.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Juan Javier-DesLogesDepartment of Urology, UC San Diego Health, La Jolla, CA, USA. Jjavierdesloges@health.ucsd.edu.
Rana R McKayDepartment of Urology, UC San Diego Health, La Jolla, CA, USA.
Austin D SwaffordDepartment of Bioengineering, UC San Diego, La Jolla, CA, USA.
Gregory D Sepich-PooreDepartment of Bioengineering, UC San Diego, La Jolla, CA, USA.
Rob KnightDepartment of Bioengineering, UC San Diego, La Jolla, CA, USA.
J Kellogg ParsonsJanssen Research and Development, San Diego, CA, USA. k0parsons@health.ucsd.edu.
UC San Diego Health System · USUniversity of California, San Diego · USJanssen (United States) · USLa Jolla Bioengineering Institute · US

Funding

Bacterial biosensors for the prevention of gastrointestinal cancersR01CA241728 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFF M HASTY, ROB KNIGHT · 2020 to 2026
$4.2M
Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)U24CA248454 · NCI · NORTHERN ARIZONA UNIVERSITY · PI CAPORASO, JAMES GREGORY · 2020 to 2024
$3.7M
Comprehensive characterization of the cancer microbiome and its immuno-oncology interfaceF30CA243480 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POORE, GREGORY DERRICK · 2020 to 2021
$73k
NCI NIH HHS F30 CA243480NCI NIH HHS R01 CA241728NCI NIH HHS U24 CA248454
6 · The paper itself

Abstract

There is growing evidence that the microbiome is involved in development and treatment of many human diseases, including prostate cancer. There are several potential pathways for microbiome-based mechanisms for the development of prostate cancer: direct impacts of microbes or microbial products in the prostate or the urine, and indirect impacts from microbes or microbial products in the gastrointestinal tract. Unique microbial signatures have been identified within the stool, oral cavity, tissue, urine, and blood of prostate cancer patients, but studies vary in their findings. Recent studies describe potential diagnostic and therapeutic applications of the microbiome, but further clinical investigation is needed. In this review, we explore the existing literature on the discovery of the human microbiome and its relationship to prostate cancer.

Indexed as

MicrobiotaProstatic NeoplasmsFecesHumansMaleProstate

Identifiers

PMID34267333
PMCPMC8767983
OpenAlexW3182826362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.