Evidence map›Paper›PMID 34267298›Full record

ArticleScientific reports2021

Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents.

Javier Mussin, Viviana Robles-Botero, Rocío Casañas-Pimentel, Florencia Rojas, Letizia Angiolella, Eduardo San Martín-Martínez, Gustavo Giusiano

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Review
  3. Antimicrobial Effect of Silver Nanoparticles Capped withNanomaterials (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Eco-Friendly Synthesis and Characterization ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  7. Plant-Mediated Fabrication of Silver Nanoparticles UsingBioinorganic chemistry and applications · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. UsingInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Fungal Biofilm: An Overview of the Latest Nano-Strategies.Antibiotics (Basel, Switzerland) · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Green Silver Nanoparticles: An Antibacterial Mechanism.Antibiotics (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Javier MussinMycology Department, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Av. Las Heras 727, 3500, Resistencia, Chaco, Argentina. javiermussin@hotmail.com.
Viviana Robles-BoteroCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada, CONACYT - Instituto Politécnico Nacional, Mexico City, Mexico.
Rocío Casañas-PimentelCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada, CONACYT - Instituto Politécnico Nacional, Mexico City, Mexico.
Florencia RojasMycology Department, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Av. Las Heras 727, 3500, Resistencia, Chaco, Argentina.
Letizia AngiolellaDepartment of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Eduardo San Martín-MartínezCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada - Legaria, Instituto Politécnico Nacional, Mexico City, Mexico.
Gustavo GiusianoMycology Department, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Av. Las Heras 727, 3500, Resistencia, Chaco, Argentina.
Centro Científico Tecnológico - Nordeste · ARInstituto Politécnico Nacional · MXConsejo Nacional de Humanidades, Ciencias y Tecnologías · MXNational University of the Northeast · ARSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.

Indexed as

Anti-Infective AgentsAntioxidantsAsteraceaeFlavonoidsGreen Chemistry TechnologyHumansLeukocytes, MononuclearMetal NanoparticlesMicrobial Sensitivity TestsPhenolsPlant ExtractsSilverSkin Diseases, InfectiousSoft Tissue InfectionsAnti-Infective AgentsAntioxidantsFlavonoidsPhenolsPlant ExtractsSilver

Identifiers

PMID34267298
PMCPMC8282796
OpenAlexW3178362822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.