Evidence map›Paper›PMID 34267242›Full record

ArticleScientific reports2021

Type 1 diabetes patients increase CXCR4

Guy S Taylor, Andy Shaw, Kieran Smith, Tess E Capper, Jadine H Scragg, Michael Cronin, Ayat Bashir, Anneliese Flatt, Matthew D Campbell, Emma J Stevenson and 3 more

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Guy S TaylorPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Andy ShawPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Kieran SmithPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Tess E CapperPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Jadine H ScraggPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Michael CroninLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Ayat BashirTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Anneliese FlattTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Matthew D CampbellFaculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, UK.
Emma J StevensonPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
James A ShawTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Mark RossSchool of Applied Sciences, Edinburgh Napier University, Edinburgh, UK.
Daniel J WestPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK. daniel.west@newcastle.ac.uk.
Newcastle University · GBEdinburgh Napier University · GBQueen's University Belfast · GBUniversity of Leeds · GBUniversity of Oxford · GBUniversity of Sunderland · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along with investigating how T1D influences exercise-induced increases of other angiogenic cells (hematopoietic progenitor cells; HPCs) and cell surface expression of chemokine receptor 4 (CXCR4) and 7 (CXCR7), is needed. Thirty T1D patients and 30 matched non-diabetes controls completed 45 min of incline walking. Circulating HPCs (CD34

Indexed as

AdultDiabetes Mellitus, Type 1Endothelial Progenitor CellsExerciseFemaleHematopoietic Stem CellsHumansMaleMiddle AgedReceptors, CXCRReceptors, CXCR4Vascular Endothelial Growth Factor Receptor-2ACKR3 protein, humanCXCR4 protein, humanKDR protein, humanReceptors, CXCRReceptors, CXCR4Vascular Endothelial Growth Factor Receptor-2

Identifiers

PMID34267242
PMCPMC8282661
OpenAlexW3176129188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.