Evidence map›Paper›PMID 34267232›Full record

ArticleScientific reports2021

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X

Kamal A Qureshi, Avinash D Bholay, Pankaj K Rai, Hamdoon A Mohammed, Riaz A Khan, Faizul Azam, Mariusz Jaremko, Abdul-Hamid Emwas, Piotr Stefanowicz, Mateusz Waliczek and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Characterization and Production of Antimicrobial Compound byInternational journal of microbiology · 2026
    Article
  3. Investigation of antimicrobial synergism of actinomycin derivatives fromTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  4. Article
  5. Actinomycin Analogs from Soil-DerivedLife (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Actinomycins from Soil-InhabitingMolecules (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. PeerJ · 2023
    Article
  17. Article
  18. Overview on Strategies and Assays for Antibiotic Discovery.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kamal A QureshiFaculty of Biosciences and Biotechnology, Invertis University, Bareilly, UP, 243123, India. ka.qurishe@qu.edu.sa.
Avinash D BholayDepartment of Microbiology, KTHM College, Savitribai Phule Pune University, Nashik, MS, 422002, India.
Pankaj K RaiFaculty of Biosciences and Biotechnology, Invertis University, Bareilly, UP, 243123, India.
Hamdoon A MohammedDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Qassim, 51452, Saudi Arabia.
Riaz A KhanDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Qassim, 51452, Saudi Arabia.
Faizul AzamDepartment of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Unaizah, Qassim, 51911, Saudi Arabia.
Mariusz JaremkoBiological and Environmental Sciences and Engineering Division (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia. mariusz.jaremko@kaust.edu.sa.
Abdul-Hamid EmwasCore Labs, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Piotr StefanowiczFaculty of Chemistry, University of Wroclaw, F. Joliot-Curie, Street-14, 50-383, Wroclaw, Poland.
Mateusz WaliczekFaculty of Chemistry, University of Wroclaw, F. Joliot-Curie, Street-14, 50-383, Wroclaw, Poland.
Monika KijewskaFaculty of Chemistry, University of Wroclaw, F. Joliot-Curie, Street-14, 50-383, Wroclaw, Poland.
Ehab A RagabDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, 11371, Egypt.
Medhat RehanDepartment of Genetics, Faculty of Agriculture, Kafr El-Sheikh University, Kafr El-Sheikh, 33516, Egypt.
Gamal O ElhassanDepartment of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah, Qassim, 51911, Saudi Arabia.
Md Jamir AnwarDepartment of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah, Qassim, 51911, Saudi Arabia.
Dinesh K PrajapatiFaculty of Biosciences and Biotechnology, Invertis University, Bareilly, UP, 243123, India. dinesh.p@invertis.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptomyces smyrnaeus UKAQ_23, isolated from the mangrove-sediment, collected from Jubail,Saudi Arabia, exhibited substantial antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), including non-MRSA Gram-positive test bacteria. The novel isolate, under laboratory-scale conditions, produced the highest yield (561.3 ± 0.3 mg/kg fermented agar) of antimicrobial compounds in modified ISP-4 agar at pH 6.5, temperature 35 °C, inoculum 5% v/w, agar 1.5% w/v, and an incubation period of 7 days. The two major compounds, K

Indexed as

Anti-Bacterial AgentsComputer SimulationCulture MediaDactinomycinDrug Evaluation, PreclinicalFermentationMagnetic Resonance SpectroscopyMass SpectrometryMethicillin-Resistant Staphylococcus aureusMolecular Docking SimulationMolecular StructurePhylogenyStreptomycesAnti-Bacterial AgentsCulture MediaDactinomycin

Identifiers

PMID34267232
PMCPMC8282855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.