Evidence map›Paper›PMID 34266954›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning.

Won Ho Yang, Julia S Westman, Douglas M Heithoff, Markus Sperandio, Jin Won Cho, Michael J Mahan, Jamey D Marth

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. eLife · 2024
    Article
  12. Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.International journal of molecular sciences · 2022
    Review
  20. The extracellular sialidase NEU3 primes neutrophils.Journal of leukocyte biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Won Ho YangCenter for Nanomedicine, University of California, Santa Barbara, CA 93106; bionicwono@yonsei.ac.kr jmarth@sbpdiscovery.org.ORCID 0000-0001-6214-1421
Julia S WestmanCenter for Nanomedicine, University of California, Santa Barbara, CA 93106.
Douglas M HeithoffCenter for Nanomedicine, University of California, Santa Barbara, CA 93106.
Markus SperandioWalter Brendel Center for Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilian's University, 80539 Munich, Germany.ORCID 0000-0002-7689-3613
Jin Won ChoGlycosylation Network Research Center and Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.ORCID 0000-0003-4527-1755
Michael J MahanCenter for Nanomedicine, University of California, Santa Barbara, CA 93106.ORCID 0000-0002-0103-4099
Jamey D MarthCenter for Nanomedicine, University of California, Santa Barbara, CA 93106; bionicwono@yonsei.ac.kr jmarth@sbpdiscovery.org.
University of California, Santa Barbara · USCentre of Experimental Medicine of the Slovak Academy of Sciences · SKYonsei University · KR

Funding

Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ESKO, JEFFREY D · 2016 to 2025
$26.2M
GLYCOSYLTRANSFERASE FUNCTION IN DEVELOPMENT AND DISEASER01DK048247 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMEY MARTH · 1994 to 2026
$9.4M
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and DiseaseR01AI151371 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARTH, JAMEY · 2021 to 2025
$2.4M
NHLBI NIH HHS P01 HL131474NIAID NIH HHS R01 AI151371NIDDK NIH HHS R01 DK048247
6 · The paper itself

Abstract

Intestinal inflammation is the underlying basis of colitis and the inflammatory bowel diseases. These syndromes originate from genetic and environmental factors that remain to be fully identified. Infections are possible disease triggers, including recurrent human food-poisoning by the common foodborne pathogen

Indexed as

AnimalsColitisDisease Models, AnimalFemaleHumansIntestinesMaleMiceMice, Inbred C57BLNeuraminidaseRecurrenceSalmonella Food PoisoningSalmonella typhimuriumToll-Like Receptor 4Neu3 protein, mouseNeuraminidaseTlr4 protein, mouseToll-Like Receptor 4colitisinflammationneuraminidase

Identifiers

PMID34266954
PMCPMC8307618
OpenAlexW3182543611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.