Evidence map›Paper›PMID 34266906›Full record

ArticleJournal of neurointerventional surgery2022

Finnish flow diverter study: 8 years of experience in the treatment of acutely ruptured intracranial aneurysms.

Kemal Alpay, Tero Hinkka, Antti E Lindgren, Juha-Matti Isokangas, Rahul Raj, Riitta Parkkola, Matias Sinisalo, Jussi Numminen, Juha-Pekka Pienimäki, Petri Saari and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurointerventional surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Observational
  7. The off-label uses of pipeline embolization device for complex cerebral aneurysms: Mid-term follow-up in a single center.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  8. Article
  9. Long term WEB results - still going strong at 5 years?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Kemal AlpayDepartment of Radiology, Turku University Hospital, Turku, Finland kemalp@utu.fi.ORCID http://orcid.org/0000-0002-8129-2273
Tero HinkkaDepartment of Radiology, Tampere University Hospital, Tampere, Finland.
Antti E LindgrenNeurosurgery, Kuopio University Hospital, Kuopio, Pohjois-Savo, Finland.
Juha-Matti IsokangasOulu University Hospital, Oulu, Finland.
Rahul RajDepartment of Neurosurgery, Helsinki University Central Hospital, Helsinki, Uusimaa, Finland.ORCID http://orcid.org/0000-0003-4243-9591
Riitta ParkkolaDepartment of Radiology, Turku University Hospital, Turku, Finland.
Matias SinisaloDepartment of Radiology, Turku University Hospital, Turku, Finland.
Jussi NumminenHelsinki University Central Hospital, Helsinki, Uusimaa, Finland.
Juha-Pekka PienimäkiDepartment of Radiology, Tampere University Hospital, Tampere, Finland.
Petri SaariKuopio University Hospital, Kuopio, Pohjois-Savo, Finland.
Janne SeppänenDepartment of Radiology, Tampere University Hospital, Tampere, Finland.
Kari PalosaariOulu University Hospital, Oulu, Finland.
Riitta RautioDepartment of Radiology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0001-8385-0622
Tampere University Hospital · FIHelsinki University Hospital · FIOulu University Hospital · FITurku University Hospital · FIUniversity of Turku · FIKuopio University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFlow diversion of acutely ruptured intracranial aneurysms (IAs) is controversial due to high treatment-related complication rates and a lack of supporting evidence. We present clinical and radiological results of the largest series to date.

methodsThis is a nationwide retrospective study of acutely ruptured IAs treated with flow diverters (FDs). The primary outcome was the modified Rankin Scale (mRS) score at the last available follow-up time. Secondary outcomes were treatment-related complications and the aneurysm occlusion rate.

results110 patients (64 females; mean age 55.7 years; range 12-82 years) with acutely ruptured IAs were treated with FDs between 2012 and 2020 in five centers. 70 acutely ruptured IAs (64%) were located in anterior circulation, and 47 acutely ruptured IAs (43%) were blister-like. A favorable functional outcome (mRS 0-2) was seen in 73% of patients (74/102). Treatment-related complications were seen in 45% of patients (n=49). Rebleeding was observed in 3 patients (3%). The data from radiological follow-ups were available for 80% of patients (n=88), and complete occlusion was seen in 90% of aneurysms (79/88). The data from clinical follow-ups were available for 93% of patients (n=102). The overall mortality rate was 18% (18/102).

conclusionsFD treatment yields high occlusion for acutely ruptured IAs but is associated with a high risk of complications. Considering the high mortality rate of aneurysmal subarachnoid hemorrhage, the prevention of rebleeding is crucial. Thus, FD treatment may be justified as a last resort option.

Indexed as

Aneurysm, RupturedEmbolization, TherapeuticEndovascular ProceduresIntracranial AneurysmSubarachnoid HemorrhageAdolescentAdultAgedAged, 80 and overChildFemaleFinlandHumansMiddle AgedRetrospective StudiesTreatment OutcomeAneurysmFlow DiverterHemorrhageStrokeSubarachnoid

Identifiers

PMID34266906
PMCPMC9209683
OpenAlexW3181675063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.