Evidence map›Paper›PMID 34266893›Full record

ArticleCancer research2021

Cutaneous Human Papillomaviruses and the Risk of Keratinocyte Carcinomas.

Dana E Rollison, Rossybelle P Amorrortu, Yayi Zhao, Jane L Messina, Michael J Schell, Neil A Fenske, Basil S Cherpelis, Anna R Giuliano, Vernon K Sondak, Michael Pawlita and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. RNA-Sequencing Reveals Two Subgroups of Eccrine Porocarcinomas and Poromas.Journal of cellular and molecular medicine · 2026
    Article
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  3. Review
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  5. Review
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  8. Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk.JID innovations : skin science from molecules to population health · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Dana E RollisonDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida. Dana.rollison@moffitt.org.ORCID 0000-0002-3171-8045
Rossybelle P AmorrortuDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0001-6851-0179
Yayi ZhaoDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Jane L MessinaDepartment of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-0332-0224
Michael J SchellBiostatistics and Bioinformatics Shared Resource, Moffitt Cancer Center, Tampa, Florida.
Neil A FenskeDepartment of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa, Florida.
Basil S CherpelisDepartment of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa, Florida.
Anna R GiulianoCenter for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida.
Vernon K SondakDepartment of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Michael PawlitaInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4720-8306
Sandrine McKay-ChopinInternational Agency for Research on Cancer, WHO, Lyon, France.
Tarik GheitInternational Agency for Research on Cancer, WHO, Lyon, France.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Massimo TommasinoInternational Agency for Research on Cancer, WHO, Lyon, France.ORCID 0000-0002-0890-8596
Moffitt Cancer Center · USCentre international de recherche sur le cancer · FRGerman Cancer Research Center · DEUniversity of South Florida · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Prospective study of cutaneous viral infections and non-melanoma skin cancerR01CA177586 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ROLLISON, DANA ELISE · 2014 to 2018
$3.4M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA177586World Health Organization 001
6 · The paper itself

Abstract

Cutaneous human papillomavirus (cuHPV) infections may be novel targets for skin cancer prevention and treatment, but critical information regarding the development of virus-positive skin cancers following cuHPV infection has been lacking. In this study, baseline cuHPV infection was measured by serology and viral DNA detection in eyebrow hairs (EBH) and forearm skin swabs (SSW) among 1,008 individuals undergoing routine skin cancer screening exams and followed for incidence of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cuSCC). Baseline β-HPV detection, particularly in SSW, significantly predicted cuSCC (HR = 4.32; 95% confidence interval, 1.00-18.66), whereas serologic evidence of past β-HPV infection was not associated with cuSCC. Less than 5% of baseline β-HPV types detected in SSW were present in subsequent cuSCC tumors, and cuHPV detected in SSW with higher mean fluorescence intensity values were more likely to be present in cuSCC compared with those with lower levels (

Indexed as

AlphapapillomavirusAgedAged, 80 and overBasal Cell CarcinomaBiomarkers, TumorCarcinoma, Squamous CellDNA, ViralEarly Detection of CancerFemaleFollow-Up StudiesHairHumansKeratinocytesMaleMiddle AgedNeoplasms, Basal CellBiomarkers, TumorDNA, Viral

Identifiers

PMID34266893
PMCPMC8416805
OpenAlexW3178637878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.