Evidence map›Paper›PMID 34266874›Full record

ArticleLife science alliance2021

Distinct mechanisms mediate X chromosome dosage compensation in

Claudia Isabelle Keller Valsecchi, Eric Marois, M Felicia Basilicata, Plamen Georgiev, Asifa Akhtar

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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  10. Gene-rich X chromosomes implicate intragenomic conflict in the evolution of bizarre genetic systems.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Claudia Isabelle Keller ValsecchiMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany c.keller@imb-mainz.de.ORCID 0000-0003-4135-5927
Eric MaroisUniversité de Strasbourg, Centre National de la Recherche Scientifique (CNRS) UPR9022, Inserm U1257, Strasbourg, France.ORCID 0000-0003-4147-3747
M Felicia BasilicataMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID 0000-0002-1111-9459
Plamen GeorgievMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Asifa AkhtarMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany akhtar@ie-freiburg.mpg.de.ORCID 0000-0001-8973-6193
Max Planck Institute of Immunobiology and Epigenetics · DECentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex chromosomes induce potentially deleterious gene expression imbalances that are frequently corrected by dosage compensation (DC). Three distinct molecular strategies to achieve DC have been previously described in nematodes, fruit flies, and mammals. Is this a consequence of distinct genomes, functional or ecological constraints, or random initial commitment to an evolutionary trajectory? Here, we study DC in the malaria mosquito

Indexed as

Dosage Compensation, GeneticAmino Acid SequenceAnimalsAnophelesChromosomes, InsectDNA-Binding ProteinsDrosophilaDrosophila ProteinsEvolution, MolecularFemaleGene ExpressionGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesGenome-Wide Association StudyHistone AcetyltransferasesDNA-Binding ProteinsDrosophila ProteinsHistone Acetyltransferasesmsl-2 protein, DrosophilaMultiprotein ComplexesTranscription Factors

Identifiers

PMID34266874
PMCPMC8321682
OpenAlexW3182681016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.