Evidence map›Paper›PMID 34266612›Full record

ReviewHandbook of clinical neurology2021

Neurobiology of peripartum mental illness.

Jodi L Pawluski, James E Swain, Joseph S Lonstein

Open access · greenAbstract readReview
In one paragraph

Review in Handbook of clinical neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
25.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Recent Neuroscience Advances in Human Parenting.Advances in neurobiology · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jodi L PawluskiUniv Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, Rennes, France. Electronic address: j.pawluski@gmail.com.
James E SwainDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States.
Joseph S LonsteinNeuroscience Program & Department of Psychology, Michigan State University, East Lansing, MI, United States.
Institut de Recherche en Santé, Environnement et Travail · FRMichigan State University · USStony Brook University · US

Funding

Violence Across the Lifespan - Opioids Maternal BrainR01DA047336 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI SWAIN, JAMES EDWARD · 2019 to 2024
$3.7M
Postpartum Intervention for Mothers with Opioid Use Disorders - Brain-Behavior MechanismsR33DA053688 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI Maria Muzik, James Edward Swain · 2025 to 2026
$1.5M
Childhood Poverty and Brain Development: The Role of Chronic Stress and ParentingRC2MD004767 · NIMHD · CORNELL UNIVERSITY · PI EVANS, GARY W, LIBERZON, ISRAEL · 2009 to 2010
$1.4M
Postpartum Intervention for Mothers with Opioid Use Disorders - Brain-Behavior MechanismsR61DA053688 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MUZIK, MARIA, SWAIN, JAMES EDWARD · 2022 to 2023
$799k
Prepartum and Postpartum Modification of Central SerotoninR03HD097085 · NICHD · MICHIGAN STATE UNIVERSITY · PI LONSTEIN, JOSEPH S · 2019 to 2020
$141k
NICHD NIH HHS R03 HD097085NIDA NIH HHS R01 DA047336NIDA NIH HHS R33 DA053688NIDA NIH HHS R61 DA053688NIMHD NIH HHS RC2 MD004767
6 · The paper itself

Abstract

At least one in seven pregnant or recently postpartum women will experience a mental illness such as an anxiety disorder, depressive disorder, or substance use disorder. These mental illnesses have detrimental effects on the health of the mother, child, and family, but little is known about the hypothalamic and other neural correlates of maternal mental health concerns. The transition to parenthood alone is a time of remarkable neural plasticity, so it is perhaps not surprising that current research is showing that maternal mental illness has unique neural profiles. Furthermore, the neural systems affected by peripartum mental illness overlap and interact with the systems involved in maternal caregiving behaviors, and mother-infant interactions are, therefore, highly susceptible to disruption. This review discusses what we know about the unique neural changes occurring during peripartum mental illness and the role of the hypothalamus in these illnesses. With an improved understanding of the neural correlates of maternal mental health and disease, we will be better equipped to predict risk, develop effective treatments, and ultimately prevent suffering for millions of parents during this critical time in life.

Indexed as

Mental DisordersPeripartum PeriodChildFemaleHumansInfantMaternal BehaviorMother-Child RelationsPostpartum PeriodPregnancyAnxietyHypothalamic–pituitary–adrenal axisHypothalamic–pituitary–gonadal axisMaternal behaviorMaternal brainMental illnessMotherhoodOpioidsOxytocinPostpartum depressionSubstance use disorder

Identifiers

PMID34266612
PMCPMC11736696
OpenAlexW3181822178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.