ArticleBMC microbiology2021
Benzylpenicillin-producing Trichophyton erinacei and methicillin resistant Staphylococcus aureus carrying the mecC gene on European hedgehogs - A pilot-study.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Free-ranging hedgehogs as sentinels of environmental extended-spectrum β-lactamase-producing Enterobacterales.One health (Amsterdam, Netherlands) · 2026Article
- Zoonotic dermatophyteFrontiers in veterinary science · 2026Article
- Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes.Applied and environmental microbiology · 2025Article
- Methicillin-resistant and methicillin-susceptibleOne health (Amsterdam, Netherlands) · 2024Article
- Nasal Carriage of Antimicrobial-Resistant Staphylococci by Fallow Deer (Microorganisms · 2024Article
- Clonal dissemination of successful emerging cloneOne health (Amsterdam, Netherlands) · 2023Article
- Characterisation of aPathogens (Basel, Switzerland) · 2023Article
- Genomic Evidence for Direct Transmission ofAntibiotics (Basel, Switzerland) · 2023Article
- Sequence Analysis of NovelInternational journal of molecular sciences · 2022Article
- Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.Transboundary and emerging diseases · 2022Article
- Host-driven subspeciation in the hedgehog fungus,Persoonia · 2022Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Article
- Wild Animals Are Reservoirs and Sentinels ofAntibiotics (Basel, Switzerland) · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high carriage rate of methicillin-resistant Staphylococcus aureus with the mecC gene (mecC-MRSA) has been described among Wild European hedgehogs (Europeaus erineaus). Due to this frequent occurrence, it has been suggested that hedgehogs could be a natural reservoir for mecC-MRSA. However, the reason why hedgehogs carry mecC-MRSA remains unknown, but it has been hypothesized that mecC-MRSA could have evolved on the skin of hedgehogs due to the co-occurrence with antibiotic producing dermatophytes. The aim of this pilot-study was therefore to investigate if hedgehogs in Sweden carry Trichophyton spp. and to provide evidence that these dermatophytes are able to produce penicillin or similar substances. In addition, the study aimed to identify if dermatophytes co-occurred with mecC-MRSA.
methodsSamples were collected from hedgehogs (Europeaus erineaus) that were euthanized or died of natural causes. All samples were screened for dermatophytes and mecC-MRSA using selective cultivation methods. Suspected isolates were characterized using PCR-based methods, genome sequencing and bioinformatic analyses. Identification of penicillin was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry.
resultsIn total 23 hedgehogs were investigated, and it was shown that two carried Trichophyton erinacei producing benzyl-penicillin, and that these hedgehogs also carried mecC-MRSA. The study also showed that 60% of the hedgehogs carried mecC-MRSA.
conclusionThe pilot-study demonstrated that Trichophyton erinacei, isolated from Swedish hedgehogs, can produce benzylpenicillin and that these benzylpenicillin-producing T. erinacei co-occurred with mecC-MRSA. The study also reconfirmed the high occurrence of mecC-MRSA among hedgehogs.
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