ArticleRenal failure2021
Platelet-leukocyte aggregates - a predictor for acute kidney injury after cardiac surgery.
Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of different antiplatelet therapy drugs on platelet activation and platelet-leukocyte aggregate formation in early septic ARDS.BMC pharmacology & toxicology · 2025Article
- Prognostic value of nine inflammatory biomarkers for critically ill patients with rheumatic heart disease: a retrospective study.Frontiers in immunology · 2025Article
- Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury.PloS one · 2025Article
- Assessing the Impact of Morphine on Adverse Outcomes in ACS Patients Treated with P2Y12 Inhibitors: Insights from Multiple Real-World Evidence.Drug design, development and therapy · 2024Article
- Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19.iScience · 2023Article
- Combined serum free light chain predicts prognosis in acute kidney injury following cardiovascular surgery.Renal failure · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is one of the most common complications after cardiac surgery. However, effective biomarker used for early diagnosis of AKI has not been identified. Platelet-leukocyte aggregates (PLAs) participate in inflammation and coagulation, leading to vascular lesions and tissue destruction. We designed a prospective study to assess whether PLAs can serve as a good biomarker for early diagnosis of AKI after cardiac surgery.
methodsPatients with rheumatic heart disease scheduled to undergo valve replacement surgery were enrolled. Blood samples were collected at five timepoints as follows: (a) At baseline. (b) At the end of extracorporeal circulation. (c) Arrival at intensive care unit (ICU). (d) Four-hours after the admission to ICU. (e) Twenty hours after the admission to ICU. After collection, the samples were immediately used for PLAs measurement by flow cytometry.
resultsA total of 244 patients were registered, and 15 of them were diagnosed with AKI according to the serum creatinine of KDIGO guidelines. The PLAs levels in AKI group were significantly increased 20 h after surgery (two-way repeated measure analysis of variance,
conclusionPLAs is an independent risk factor for AKI after valve replacement among patients with rheumatic heart disease.
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