ArticleStroke2021
Optic Tract Shrinkage Limits Visual Restoration After Occipital Stroke.
Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Trans-Synaptic Retrograde Retinal Degeneration After Post-Chiasmatic Stroke: A Systematic Review of Empirical Evidence.European journal of neurology · 2026Pooled it
- Training in Cortically Blinded Fields Appears to Confer Patient-Specific Benefit Against Retinal Thinning.Investigative ophthalmology & visual science · 2024Pooled it
- Advances in Technology-Assisted Visual Rehabilitation Therapies: Scoping Review.Journal of medical systems · 2026Article
- Transhemispheric optic pathway degeneration following unilateral post-geniculate lesions.Brain communications · 2026Article
- What V1 Damage Can Teach Us About Visual Perception and Learning.Annual review of vision science · 2025Review
- Evolution of Visual Field Defects After Occipital Stroke: A Quantitative Analysis.Translational vision science & technology · 2025Article
- Retinal thickness is indicative of visual loss in patients with occipital lobe infarction.Frontiers in neurology · 2025Article
- Explainable machine learning for stroke risk prediction: a comparative study with SHAP-based interpretation.Frontiers in neurology · 2025Article
- Rehabilitating homonymous visual field deficits: white matter markers of recovery-stage 2 registered report.Brain communications · 2024Article
- Association between functional network connectivity, retina structure and microvasculature, and visual performance in patients after thalamic stroke: An exploratory multi-modality study.Brain and behavior · 2024Article
- Training in cortically-blind fields confers patient-specific benefit against retinal thinning after occipital stroke.medRxiv : the preprint server for health sciences · 2023Article
- Characterization of Macular Structural and Microvascular Changes in Thalamic Infarction Patients: A Swept-Source Optical Coherence Tomography-Angiography Study.Brain sciences · 2022Article
- Neural Mechanisms of Visual Field Recovery after Perceptual Training in Cortical Blindness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Alterations of optic tract and retinal structure in patients after thalamic stroke.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Background and Purpose: Damage to the adult primary visual cortex (V1) causes vision loss in the contralateral visual hemifield, initiating a process of trans-synaptic retrograde degeneration. The present study examined functional implications of this process, asking if degeneration impacted the amount of visual recovery attainable from visual restoration training in chronic patients, and if restoration training impacted optic tract (OT) shrinkage. Methods: Magnetic resonance imaging was used to measure OT volumes bilaterally in 36 patients with unilateral occipital stroke. From OT volumes, we computed laterality indices (LI), estimating the stroke-induced OT shrinkage in each case. A subset of these chronic patients (n=14, 13±6 months poststroke) underwent an average of nearly 1 year of daily visual restoration training, which repeatedly stimulated vision in their blind field. The amount of visual field recovery was quantified using Humphrey perimetry, and post training magnetic resonance imaging was used to assess the impact of training on OT shrinkage. Results: OT LI was correlated with time since stroke: it was close to 0 (no measurable OT shrinkage) in subacute participants (<6 months poststroke) while chronic participants (>6 months poststroke) exhibited LI >0, but with significant variability. Visual training did not systematically alter LI, but chronic patients with baseline LI≈0 (no OT shrinkage) exhibited greater visual field recovery than those with LI>0. Conclusions: Unilateral OT shrinkage becomes detectable with magnetic resonance imaging by ≈7 months poststroke, albeit with significant interindividual variability. Although visual restoration training did not alter the amount of degeneration already sustained, OT shrinkage appeared to serve as a biomarker of the potential for training-induced visual recovery in chronic cortically blind patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.