ReviewInternational journal of sports medicine2022
The Molecular Signature of High-intensity Training in the Human Body.
Review in International journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Effects of high-intensity training on jumping performance among athletes: a systematic review with meta-analysis.Scientific reports · 2025Pooled it
- Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Local and Systemic Responses to Low-Intensity Cycling With Blood Flow Restriction Compared to High-Intensity Cycling: A Randomized Crossover Study.Scandinavian journal of medicine & science in sports · 2025Trial
- Effects of high-intensity interval training combined with dietary intervention on body composition, cardiovascular function, endothelial cell function and blood lipid indexes in children with obesity: a randomized controlled trial.Frontiers in public health · 2025Trial
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Acute exercise rewires the proteomic landscape of human immune cells.Nature communications · 2026Article
- Association between antioxidant status and special strength performance in combat athletes: a cross-sectional study.Frontiers in sports and active living · 2026Article
- Effects of exercise therapy on quality of life in patients with inflammatory bowel disease: a network meta-analysis.Frontiers in physiology · 2026Article
- How intense is high-intensity interval training? Biomarker responses and associations with training load and fitness.iScience · 2025Article
- Sport-Related Injuries in Portuguese CrossFitMuscles (Basel, Switzerland) · 2025Article
- Effects of swinging exercise on immune biomarkers: a systematic review and meta-analysis with machine learning-based identification of responder profiles.Frontiers in physiology · 2025Article
- Maximal and sub-maximal exercise tests alter PBMC microRNA expression: insights into sport- and sex-specific variations.Frontiers in physiology · 2025Article
- Minutes that matter: time-efficient high-intensity interval training improves cardiac function with transcriptomic evidence in post-myocardial infarction mice.Frontiers in cell and developmental biology · 2025Article
- Training Intensity Distribution of a 7-Day HIIT Shock Microcycle: Is Time in the "Red Zone" Crucial for Maximizing Endurance Performance? A Randomized Controlled Trial.Sports medicine - open · 2024Article
- Review
- The Impact of Wearing Different Face Masks on Vigorous Physical Exercise Performance and Perceived Exertion among COVID-19 Infected vs. Uninfected Female Students.European journal of investigation in health, psychology and education · 2023Article
- The Impact of Exercise Training Intensity on Physiological Adaptations and Insulin Resistance in Women with Abdominal Obesity.Healthcare (Basel, Switzerland) · 2022Article
- Treatment with EV-miRNAs Alleviates Obesity-Associated Metabolic Dysfunction in Mice.International journal of molecular sciences · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-intensity training is becoming increasingly popular outside of elite sport for health prevention and rehabilitation. This expanded application of high-intensity training in different populations requires a deeper understanding of its molecular signature in the human body. Therefore, in this integrative review, cellular and systemic molecular responses to high-intensity training are described for skeletal muscle, cardiovascular system, and the immune system as major effectors and targets of health and performance. Different kinds of stimuli and resulting homeostatic perturbations (i. e., metabolic, mechanical, neuronal, and hormonal) are reflected, taking into account their role in the local and systemic deflection of molecular sensors and mediators, and their role in tissue and organ adaptations. In skeletal muscle, a high metabolic perturbation induced by high-intensity training is the major stimulus for skeletal muscle adaptation. In the cardio-vascular system, high-intensity training induces haemodynamic stress and deflection of the Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.