Evidence map›Paper›PMID 34265670›Full record

ArticleJournal of affective disorders2021

Predicting suicide attempts and suicide deaths among adolescents following outpatient visits.

Robert B Penfold, Eric Johnson, Susan M Shortreed, Rebecca A Ziebell, Frances L Lynch, Greg N Clarke, Karen J Coleman, Beth E Waitzfelder, Arne L Beck, Rebecca C Rossom and 2 more

Abstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  10. Behavior of prediction performance metrics with rare events.Journal of clinical epidemiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Robert B PenfoldKaiser Permanente Washington Health Research Institute, Seattle, WA 98101 USA. Electronic address: robert.b.penfold@kp.org.
Eric JohnsonKaiser Permanente Washington Health Research Institute, Seattle, WA 98101 USA.
Susan M ShortreedKaiser Permanente Washington Health Research Institute, Seattle, WA 98101 USA.
Rebecca A ZiebellKaiser Permanente Washington Health Research Institute, Seattle, WA 98101 USA.
Frances L LynchKaiser Permanente Northwest Center for Health Research, Portland, OR 97227 USA.
Greg N ClarkeKaiser Permanente Northwest Center for Health Research, Portland, OR 97227 USA.
Karen J ColemanKaiser Permanente Southern California Department of Research and Evaluation, Pasadena, CA 91101 USA.
Beth E WaitzfelderKaiser Permanente Hawaii Center for Health Research, Honolulu HI 96817 USA.
Arne L BeckKaiser Permanente Colorado Institute for Health Research, Denver, CO 80231 USA.
Rebecca C RossomHealthPartners Institute, Minneapolis, MN 55425 USA.
Brian K AhmedaniHenry Ford Health System, Center for Health Policy & Health Services Research, Detroit, MI 48202.
Gregory E SimonKaiser Permanente Washington Health Research Institute, Seattle, WA 98101 USA.

Funding

SSRI's and SuicidalityU19MH092201 · NIMH · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIMON, GREGORY E. · 2010 to 2018
$19.5M
Whose Depression Are We Measuring?: Considering the role of place on Black women’s depression outcomesU19MH121738 · NIMH · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIMON, GREGORY E. · 2019 to 2023
$10.6M
NIMH NIH HHS U19 MH092201NIMH NIH HHS U19 MH121738
6 · The paper itself

Abstract

backgroundFew studies report on machine learning models for suicide risk prediction in adolescents and their utility in identifying those in need of further evaluation. This study examined whether a model trained and validated using data from all age groups works as well for adolescents or whether it could be improved.

methodsWe used healthcare data for 1.4 million specialty mental health and primary care outpatient visits among 256,823 adolescents across 7 health systems. The prediction target was 90-day risk of suicide attempt following a visit. We used logistic regression with least absolute shrinkage and selection operator (LASSO) and generalized estimating equations (GEE) to predict risk. We compared performance of three models: an existing model, a recalibrated version of that model, and a newly-learned model. Models were compared using area under the receiver operating curve (AUC), sensitivity, specificity, positive predictive value and negative predictive value.

resultsThe AUC produced by the existing model for specialty mental health visits estimated in adolescents alone (0.796; [0.789, 0.802]) was not significantly different than the AUC of the recalibrated existing model (0.794; [0.787, 0.80]) or the newly-learned model (0.795; [0.789, 0.801]). Predicted risk following primary care visits was also similar: existing (0.855; [0.844, 0.866]), recalibrated (0.85 [0.839, 0.862]), newly-learned (0.842, [0.829, 0.854]). LIMITATIONS: The models did not incorporate non-healthcare risk factors. The models relied on ICD9-CM codes for diagnoses and outcome measurement.

conclusionsPrediction models already in operational use by health systems can be reliably employed for identifying adolescents in need of further evaluation.

Indexed as

OutpatientsSuicide, AttemptedAdolescentHumansLogistic ModelsRisk AssessmentRisk FactorsAdolescentsMachine learningSuicide

Identifiers

PMID34265670
PMCPMC8820270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.