Evidence map›Paper›PMID 34265626›Full record

ArticlePsychiatry research. Neuroimaging2021

Altruism and "love of neighbor" offer neuroanatomical protection against depression.

Lisa Miller, Priya Wickramaratne, Xuejun Hao, Clayton H McClintock, Lifang Pan, Connie Svob, Myrna M Weissman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Exploring the Impacts of Preventative Health Behaviors with Respect to COVID-19: An Altruistic Perspective.International journal of environmental research and public health · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lisa MillerSpirituality Mind Body Institute, Clinical Psychology Program, Teachers College, Columbia University, New York City, USA. Electronic address: lfm14@tc.columbia.edu.
Priya WickramaratneDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA; Division of Translational Epidemiology, New York State Psychiatric Institute, New York City, USA.
Xuejun HaoDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA; Division of Translational Epidemiology, New York State Psychiatric Institute, New York City, USA.
Clayton H McClintockSpirituality Mind Body Institute, Clinical Psychology Program, Teachers College, Columbia University, New York City, USA; Sierra Pacific MIRECC, San Francisco VA Health Care System, San Francisco, USA; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, USA.
Lifang PanDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA; Division of Translational Epidemiology, New York State Psychiatric Institute, New York City, USA.
Connie SvobDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA; Division of Translational Epidemiology, New York State Psychiatric Institute, New York City, USA.
Myrna M WeissmanDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA; Division of Translational Epidemiology, New York State Psychiatric Institute, New York City, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, USA.

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
NIMH NIH HHS R01 MH036197
6 · The paper itself

Abstract

We prospectively investigate protective benefits against depression of cortical thickness across nine regions of a Ventral Frontotemporal Network (VFTN), previously associated with spiritual experience. Seventy-two participants at high and low risk for depression (Mean age 41 years; 22-63 years; 40 high risk, 32 low risk) were drawn from a three-generation, thirty-eight year study. FreeSurfer estimated cortical thickness over anatomical MRIs of the brain (Year 30) for each of the nine ROIs. Depression (MDD with SAD-L; symptoms with PHQ; Years 30 and 38) and spirituality (self-report on five phenotypes; Year 35), respectively, were associated with the weighted average of nine regions of interest. VFTN thickness was: 1) positively associated (p<0.01) with two of five spiritual phenotypes, altruism and love of neighbor, interconnectedness at a trend level, but neither commitment nor practice, 2) inversely associated with a diagnosis of MDD (SADS-L Year 30, for any MDD in the past ten years), and 3) prospectively neuroanatomically protective against depressive symptoms (PHQ-9 Year 38) for those at high familial risk.

Indexed as

AltruismMajor Depressive DisorderAdultBrainHumansMagnetic Resonance ImagingSpiritualityAltruismDepressionHigh RiskLove of neighborMRISpirituality

Identifiers

PMID34265626
PMCPMC8672211

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.