Evidence map›Paper›PMID 34265539›Full record

ReviewAutonomic neuroscience : basic & clinical2021

Preparing for the long-haul: Autonomic complications of COVID-19.

Nicholas W Larsen, Lauren E Stiles, Mitchell G Miglis

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05566483 narecruitingnot on this mapstarted 2023, after this paper: background citation

Physiological Underpinnings of Post-Acute Sequelae of SARS CoV-2 ("Long COVID") and Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity

TypeinterventionalSponsorUniversity of Colorado, DenverRan2023 to 2027Enrolled30ConditionsPost-acute Sequelae of SARS-CoV-2 InfectionArmsExercise
NCT06953661 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study

TypeinterventionalSponsorStanford UniversityRan2025 to 2026Enrolled20ConditionsPostural Tachycardia SyndromeArmsStellate ganglion block, Sham injection of saline, Ropivacaine, Normal saline
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 94 citations in OpenAlex.

  1. An open trial of biofeedback for long COVID.Journal of psychosomatic research · 2024
    Trial
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Autonomic dysfunction and quality of life in a cohort of neurology outpatients with post-acute sequelae of COVID-19, a two-year follow-up study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. 'The Second Arrow': A Collaborative Autoethnographic Exploration of What Can Be Learned From One Long COVID Journey.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Review
  17. Article
  18. Long COVID: From olfactory dysfunctions to viral Parkinsonism.World journal of otorhinolaryngology - head and neck surgery · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nicholas W LarsenDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.
Lauren E StilesDepartment of Neurology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY, USA.
Mitchell G MiglisDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA. Electronic address: mmiglis@stanford.edu.
Stanford University · USStony Brook School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As global numbers of COVID-19 grow, chronic neurological symptoms, including those of autonomic dysfunction, are being reported with increasing frequency. Mounting evidence suggests that many patients experience chronic and sometimes debilitating symptoms long after their acute infectious period, leading to the new diagnostic category of post-acute COVID syndrome. Many symptoms of post-acute COVID syndrome appear autonomic in nature, suggesting that autonomic impairment may play a central role in the underlying pathophysiology. In this review, we discuss the autonomic symptoms and manifestations of post-acute COVID syndrome, potential mechanisms involved, and future directions for a better understanding of this novel condition.

Indexed as

Autonomic Nervous System DiseasesCOVID-19HumansPost-Acute COVID-19 SyndromeAutonomicChronicCOVIDDysautonomiaLong-haul COVIDPost-acute COVIDPost-COVIDPOTS

Identifiers

PMID34265539
PMCPMC8254396
OpenAlexW3179172073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.