Evidence map›Paper›PMID 34265315›Full record

ArticleOphthalmology2022

Endophthalmitis Rate in Immediately Sequential versus Delayed Sequential Bilateral Cataract Surgery within the Intelligent Research in Sight (IRIS®) Registry Data.

Megan Lacy, Timothy-Paul H Kung, Julia P Owen, Ryan T Yanagihara, Marian Blazes, Suzann Pershing, Leslie G Hyman, Russell N Van Gelder, Aaron Y Lee, Cecilia S Lee and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

  1. Observational
  2. Article
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  4. Incidence and clinical characteristics of acute infectious endophthalmitis after approximately 2.03 million cataract surgeries in China over a 5-year period (2017-2021).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  5. Review
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  10. Recent trends and outcomes in immediate and delayed sequential bilateral cataract surgeries: a nationwide cohort study in South Korea.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Megan LacyDepartment of Ophthalmology, University of Washington, Seattle, Washington.
Timothy-Paul H KungDepartment of Ophthalmology, University of Washington, Seattle, Washington; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York.
Julia P OwenDepartment of Ophthalmology, University of Washington, Seattle, Washington.
Ryan T YanagiharaDepartment of Ophthalmology, University of Washington, Seattle, Washington.
Marian BlazesDepartment of Ophthalmology, University of Washington, Seattle, Washington.
Suzann PershingDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California; Veterans Affairs Palo Alto Health California System, Palo Alto, California.
Leslie G HymanThe Vision Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
Russell N Van GelderDepartment of Ophthalmology, University of Washington, Seattle, Washington; Roger and Angie Karalis Johnson Retina Center, Seattle, Washington.
Aaron Y LeeDepartment of Ophthalmology, University of Washington, Seattle, Washington; Roger and Angie Karalis Johnson Retina Center, Seattle, Washington.
Cecilia S LeeDepartment of Ophthalmology, University of Washington, Seattle, Washington; Roger and Angie Karalis Johnson Retina Center, Seattle, Washington. Electronic address: leecs2@uw.edu.
IRIS® Registry Analytic Center Consortium
University of Washington · USUniversity at Buffalo, State University of New York · USVA Palo Alto Health Care System · USWills Eye Hospital · US

Funding

Aging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI TIRIN MOORE · 2017 to 2026
$8.0M
Epidemiology and clinical outcomes of diabetic macular edemaK23EY029246 · NEI · UNIVERSITY OF WASHINGTON · PI LEE, AARON · 2018 to 2022
$1.1M
NEI NIH HHS K23 EY029246NEI NIH HHS P30 EY026877NIA NIH HHS R01 AG060942
6 · The paper itself

Abstract

purposeTo compare the rate of postoperative endophthalmitis after immediately sequential bilateral cataract surgery (ISBCS) versus delayed sequential bilateral cataract surgery (DSBCS) using the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry database.

designRetrospective cohort study.

participantsPatients in the IRIS Registry who underwent cataract surgery from 2013 through 2018.

methodsPatients who underwent cataract surgery were divided into 2 groups: (1) ISBCS and (2) DSBCS (second-eye surgery ≥1 day after the first-eye surgery) or unilateral surgery. Postoperative endophthalmitis was defined as endophthalmitis occurring within 4 weeks of surgery by International Classification of Diseases (ICD) code and ICD code with additional clinical criteria.

main outcome measuresRate of postoperative endophthalmitis.

resultsOf 5 573 639 IRIS Registry patients who underwent cataract extraction, 165 609 underwent ISBCS, and 5 408 030 underwent DSBCS or unilateral surgery (3 695 440 DSBCS, 1 712 590 unilateral surgery only). A total of 3102 participants (0.056%) met study criteria of postoperative endophthalmitis with supporting clinical findings. The rates of endophthalmitis in either surgery eye between the 2 surgery groups were similar (0.059% in the ISBCS group vs. 0.056% in the DSBCS or unilateral group; P = 0.53). Although the incidence of endophthalmitis was slightly higher in the ISBCS group compared with the DSBCS or unilateral group, the odds ratio did not reach statistical significance (1.08; 95% confidence interval, 0.87-1.31; P = 0.47) after adjusting for age, sex, race, insurance status, and comorbid eye disease. Seven cases of bilateral endophthalmitis with supporting clinical data in the DSBCS group and no cases in the ISBCS group were identified.

conclusionsRisk of postoperative endophthalmitis was not statistically significantly different between patients who underwent ISBCS and DSBCS or unilateral cataract surgery.

Indexed as

RegistriesVisual AcuityAdolescentAdultAgedAged, 80 and overCataract ExtractionChildChild, PreschoolDatabases, FactualEndophthalmitisFemaleFollow-Up StudiesHumansIncidenceInfantComplicationsCOVID-19Delayed sequential bilateral cataract surgery (DSBCS)Immediately sequential bilateral cataract surgery (ISBCS)Intelligent Research in Sight Registry (IRIS® Registry)OutcomesPostoperative endophthalmitisSame-day bilateral cataract surgerySARS-CoV-2Simultaneous bilateral cataract surgery

Identifiers

PMID34265315
PMCPMC8755857
OpenAlexW3181600390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.