Evidence map›Paper›PMID 34265279›Full record

ArticleBiochemical pharmacology2021

PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.

Yunhui Xu, Krista L Denning, Yongke Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yunhui XuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1700 3rd Avenue, Huntington WV 25755, USA.
Krista L DenningDepartment of Pathology, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, WV 25755, USA.
Yongke LuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1700 3rd Avenue, Huntington WV 25755, USA; Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1700 3rd Avenue, Huntington WV 25755, USA. Electronic address: luy@marshall.edu.
Marshall University · US

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Nicotine and Alcoholic Liver DiseaseR01AA024723 · NIAAA · MARSHALL UNIVERSITY · PI LU, YONGKE · 2016 to 2020
$1.8M
NIAAA NIH HHS R01 AA024723NIGMS NIH HHS P20 GM103434
6 · The paper itself

Abstract

Fibroblast growth factor 21 (FGF21) is mainly regulated by peroxisome proliferator-activated receptor α (PPARα) in liver. The PPARα-FGF21 axis protects against alcohol-related liver disease (ALD). FGF21 exerts its effect via FGF receptor 1 (FGFR1). However, liver specific FGFR1 abrogation had no effect on ALD. Adipose tissues highly express FGFR1. When adipocyte specific FGFR1 knockout (fgfr1

Indexed as

Adipose TissueAnimalsAtrophyEthanolFatty Liver, AlcoholicFemaleMiceMice, KnockoutPeroxisome ProliferatorsPPAR alphaPyrimidinesReceptor, Fibroblast Growth Factor, Type 1EthanolFgfr1 protein, mousePeroxisome Proliferatorspirinixic acidPPAR alphaPyrimidinesReceptor, Fibroblast Growth Factor, Type 1ALOX5COX2Fibroblast growth factor 21 (FGF21)GPX4iNOSOxidative stress

Identifiers

PMID34265279
PMCPMC8549793
OpenAlexW3179096460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.