Evidence map›Paper›PMID 34265261›Full record

ArticleBiophysical journal2021

ColBuilder: A server to build collagen fibril models.

Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Aysecan Ünal, Frauke Gräter

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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  9. Deciphering the folding code of collagens.Nature communications · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Agnieszka Obarska-KosinskaHeidelberg Institute for Theoretical Studies, Heidelberg, Germany; Hamburg Unit c/o DESY, European Molecular Biology Laboratory, Hamburg, Germany.
Benedikt RennekampHeidelberg Institute for Theoretical Studies, Heidelberg, Germany; Max Planck School Matter-to-Life (MtL), Heidelberg, Germany; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
Aysecan ÜnalHeidelberg Institute for Theoretical Studies, Heidelberg, Germany; Max Planck School Matter-to-Life (MtL), Heidelberg, Germany.
Frauke GräterHeidelberg Institute for Theoretical Studies, Heidelberg, Germany; Max Planck School Matter-to-Life (MtL), Heidelberg, Germany; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany. Electronic address: frauke.graeter@h-its.org.
Heidelberg University · DEEuropean Molecular Biology Laboratory · DEHeidelberg Institute for Theoretical Studies · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type I collagen is the main structural component of many tissues in the human body. It provides excellent mechanical properties to connective tissue and acts as a protein interaction hub. There is thus a wide interest in understanding the properties and diverse functions of type I collagen at the molecular level. A precondition is an atomistic collagen I structure as it occurs in native tissue. To this end, we built full-atom models of cross-linked collagen fibrils by integrating the low-resolution structure of collagen fibril available from x-ray fiber diffraction with high-resolution structures of short collagen-like peptides from x-ray crystallography and mass spectrometry data. We created a Web resource of collagen models for 20 different species with a large variety of cross-link types and localization within the fibril to facilitate structure-based analyses and simulations of type I collagen in health and disease. To easily enable simulations, we provide parameters of the modeled cross-links for an Amber force field. The repository of collagen models is available at https://colbuilder.h-its.org.

Indexed as

CollagenExtracellular MatrixCollagen Type IConnective TissueHumansX-Ray DiffractionCollagenCollagen Type I

Identifiers

PMID34265261
PMCPMC8456305
OpenAlexW3181625958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.