Evidence map›Paper›PMID 34265248›Full record

ArticleCell host & microbe2021

Long live the king: Toxoplasma gondii nucleomodulin inhibits necroptotic cell death.

Lindsey A Shallberg, Christopher A Hunter

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lindsey A ShallbergDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 310F Hill Pavilion, 380 South University Ave, Philadelphia, PA 19104-4539, USA.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 310F Hill Pavilion, 380 South University Ave, Philadelphia, PA 19104-4539, USA. Electronic address: chunter@vet.upenn.edu.

Funding

PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISR01AI041158 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 1996 to 2019
$4.8M
NIAID NIH HHS R01 AI041158NIAID NIH HHS T32 AI007532
6 · The paper itself

Abstract

Toxoplasma gondii is a parasite that results in chronic infection of the central nervous system, but the basis for its ability to persist is unknown. In this issue of Cell Host & Microbe, Rosenberg and Sibley (2021) identify a parasite effector produced by the latent bradyzoite stage that inhibits host cell necroptosis.

Indexed as

ToxoplasmaAnimalsCell DeathLife Cycle Stages

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.