Evidence map›Paper›PMID 34265205›Full record

ArticleACS infectious diseases2021

Structure-Activity Relationships of the Enterococcal Cytolysin.

Imran R Rahman, Alondra Sanchez, Weixin Tang, Wilfred A van der Donk

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Bibacillin 1: A two-component lantibiotic frombioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Use of a head-to-tail peptide cyclase to prepare hybrid RiPPs.Chemical communications (Cambridge, England) · 2024
    Article
  7. Expression of Lanthipeptides in Human Cells.bioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alondra Sanchez
Wilfred A van der DonkORCID 0000-0002-5467-7071
University of Illinois Urbana-Champaign · USHoward Hughes Medical Institute · US

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
4800 Plus MALDI TOF/TOF AnalyzerS10RR027109 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2010 to 2010
$395k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR027109NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

Enterococcal cytolysin is a hemolytic virulence factor linked to human disease and increased patient mortality. Produced by pathogenic strains of

Indexed as

EnterococcusEnterococcus faecalisAnimalsCytotoxinsHumansStructure-Activity RelationshipVirulence FactorsCytotoxinsVirulence FactorsantibioticE. faecalishemolysislanthipeptidelantibioticliver diseasepeptide staplingRiPP

Identifiers

PMID34265205
PMCPMC8957224
OpenAlexW3178810282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.