ArticlePLoS neglected tropical diseases2021
The epidemic of Q fever in 2018 to 2019 in Zhuhai city of China determined by metagenomic next-generation sequencing.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 43 citations in OpenAlex.
- Surveillance forOne health (Amsterdam, Netherlands) · 2026Article
- Molecular study ofOne health (Amsterdam, Netherlands) · 2026Article
- Clinical efficacy of plasma cell-free DNA metagenomic next-generation sequencing in diagnosing bloodstream infections.BMC infectious diseases · 2026Article
- Molecular and Serological Detection of Coxiella burnetii in Small Ruminants in Northeastern Brazil.Veterinary medicine and science · 2026Article
- Clinical value of metagenomic next-generation sequencing in diagnosis of Coxiella burnetii infection.BMC infectious diseases · 2025Article
- Clinical application of acute Q fever -induced systemic capillary leak syndrome in a patient by using metagenomic next-generation sequencing: a case report and literature review.BMC infectious diseases · 2025Review
- Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii.BMC infectious diseases · 2025Article
- Article
- Q fever diagnosed using metagenomic next-generation sequencing in Guangdong Province, China.Biosafety and health · 2024Article
- Molecular Epidemiology of Ticks and Tick-Borne Pathogens in the Ta-Pa Mountain Area of Chongqing, China.Pathogens (Basel, Switzerland) · 2024Article
- The epidemiological and infectious characteristics of novel types of Coxiella burnetii co-infected with Coxiella-like microorganisms from Xuyi County, Jiangsu province, China.BMC infectious diseases · 2024Article
- Article
- Crescentic Glomerulonephritis and Portal Hypertension with Chronic Q Fever: A Case Report and Comprehensive Literature Review.Infection and drug resistance · 2024Article
- Prevalence and risk factors of coxiellosis in meat goat herds: an epidemiological investigation in Northeastern Thailand.International journal of veterinary science and medicine · 2024Article
- A review of coxiellosis (Q fever) and brucellosis in goats and humans: Implications for disease control in smallholder farming systems in Southeast Asia.One health (Amsterdam, Netherlands) · 2023Review
- Seroprevalence and factors associated with Coxiella burnetii exposure in goats in Moretele.The Onderstepoort journal of veterinary research · 2023Article
- Lysosomal trafficking regulator restricts intracellular growth ofFrontiers in cellular and infection microbiology · 2023Article
- Diagnosis of Acute Q Fever in a Patient by Using Metagenomic Next-Generation Sequencing: A Case Report.Infection and drug resistance · 2023Article
- Case report: a missed case of chronic Q fever infective endocarditis demonstrating the ongoing diagnostic challenges.Access microbiology · 2023Article
- Skin infectome of patients with a tick bite history.Frontiers in cellular and infection microbiology · 2023Article
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Authors and funding
24 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Q fever is a worldwide zoonosis caused by Coxiella burnetii (Cb). From January 2018 to November 2019, plasma samples from 2,382 patients with acute fever of unknown cause at a hospital in Zhuhai city of China were tested using metagenomic next-generation sequencing (mNGS). Of those tested, 138 patients (5.8%) were diagnosed with Q fever based on the presence of Cb genomic DNA detected by mNGS. Among these, 78 cases (56.5%) presented from Nov 2018 to Mar 2019, suggesting an outbreak of Q fever. 55 cases with detailed clinical information that occurred during the outbreak period were used for further analysis. The vast majority of plasma samples from those Cb-mNGS-positive patients were positive in a Cb-specific quantitative polymerase chain reaction (n = 38) and/or indirect immunofluorescence assay (n = 26). Mobile phone tracing data was used to define the area of infection during the outbreak. This suggested the probable infection source was Cb-infected goats and cattle at the only official authorized slaughterhouse in Zhuhai city. Phylogenic analysis based on genomic sequences indicated Cb strains identified in the patients, goat and cattle were formed a single branch, most closely related to the genomic group of Cb dominated by strains isolated from goats. Our study demonstrates Q fever was epidemic in 2018-2019 in Zhuhai city, and this is the first confirmed epidemic of Q fever in a contemporary city in China.
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