ArticlePLoS biology2021
Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
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- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.Nature communications · 2024Article
- Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.Science (New York, N.Y.) · 2024Article
- Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography.Journal of biomedical optics · 2023Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- High throughput detection of capillary stalling events with Bessel beam two-photon microscopy.Neurophotonics · 2023Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.bioRxiv : the preprint server for biology · 2023Article
- Could respiration-driven blood oxygen changes modulate neural activity?Pflugers Archiv : European journal of physiology · 2023Review
- Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
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- Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide.Neurophotonics · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have been interpreted as being driven by neural activity, the origin of these 1/f-like oscillations is not well understood. Here, to gain insight of the origin of the 1/f-like oxygen fluctuations, we investigated the dynamics of tissue oxygenation and neural activity in awake behaving mice. We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential did not show corresponding 1/f-like fluctuations. When local neural activity was suppressed, the 1/f-like fluctuations in oxygen concentration persisted. Two-photon measurements of erythrocyte spacing fluctuations and mathematical modeling show that stochastic fluctuations in erythrocyte flow could underlie 1/f-like dynamics in oxygenation. These results suggest that the discrete nature of erythrocytes and their irregular flow, rather than fluctuations in neural activity, could drive 1/f-like fluctuations in tissue oxygenation.
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