Evidence map›Paper›PMID 34264915›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2021

N3 (> 6 cm) squamous cell carcinoma of the head and neck: outcomes and predictive factors in 104 patients.

Selima Sellami, Jean Christophe Leclere, François Lucia, Yves Gobel, Arnaud Uguen, Jean Rousset, Dominique Gouders, Olivier Pradier, Rémi Marianowski, Ronan Abgral and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Selima SellamiOncology Department, University Hospital, Brest, France.
Jean Christophe LeclereOncology Department, University Hospital, Brest, France.
François LuciaOncology Department, University Hospital, Brest, France.
Yves GobelHead and Neck Surgery Unit, University Hospital, Brest, France.
Arnaud UguenPathology Unit, University Hospital, Brest, France.
Jean RoussetDepartment of Radiology, University Hospital of Brest and Military Hospital, Brest, France.
Dominique GoudersRadiation Oncology Department, Hospital de Cornouaille, Quimper, France.
Olivier PradierOncology Department, University Hospital, Brest, France.
Rémi MarianowskiHead and Neck Surgery Unit, University Hospital, Brest, France.
Ronan AbgralNuclear Medicine, University Hospital, Brest, France.
Ulrike SchickOncology Department, University Hospital, Brest, France.
Centre Hospitalier Régional Universitaire de Brest · FRCentre Hospitalier de Cornouaille · FRInserm · FRLaboratoire de Traitement de l'Information Médicale · FRUniversité de Bretagne Occidentale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report outcome and predictive factors in patients with N3 (> 6 cm) non-metastatic locally advanced head and neck squamous cell carcinoma (LAHNSCC) treated with a conservative approach or with initial surgery.

methods104 patients were included: 69 treated with radiotherapy (RT) ± chemotherapy (CT) and 35 with nodal surgery with or without primary tumour resection, which was completed in 30 patients by adjuvant RT ± CT. Positron-emission tomography-computed tomography (PET-CT) guided surveillance after RT ± CT was standard.

resultsTwo-year overall survival (OS) and locoregional control (LRC) were 39.4% and 37.5%, respectively. In univariate analysis, body mass index (BMI), performance status (PS), p16 status and haemoglobin value influenced OS and disease-free survival (DFS). In multivariate analysis, p16 positive status and BMI ≥ 25 remained independent prognostic factors for better OS (p = 0.023) and DFS (p = 0.002). Only under/normal weight remained an independent and adverse significant prognostic factor in multivariate analysis for regional control (RC). Patients treated with primary RT ± CT had slightly better 2-year OS (43.5%

conclusionsPatients with N3 LAHNSCC have poor prognosis, but long term LRC is achievable, especially in overweight patients and those with a good PS.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsHumansPositron Emission Tomography Computed TomographyPrognosisRadiotherapy, AdjuvantRetrospective StudiesSquamous Cell Carcinoma of Head and Neckhead and neck cancerN3 (> 6 cm)prognostic factorsradiotherapysurgery

Identifiers

PMID34264915
PMCPMC8283407
OpenAlexW3177908746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.