ArticleThe Journal of clinical investigation2021
Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.
Article in The Journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03190954 (Brain Dopaminergic Signaling in Opioid Use Disorders), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Disruption of circadian rhythms promotes alcohol use: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Pooled it
- Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.Nature communications · 2025Trial
- Blunted modulation of hierarchical brain organization in opioid use disorder.Research square · 2026Article
- Article
- Tonic dopamine sensing reveals a D2 and D3-mediated dopamine response to raclopride inNpj biosensing · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Tonic Dopamine Sensing Reveals a D2/D3 Mediated Dopamine Response to Raclopride in ClockΔ19 Mice Model.Research square · 2025Article
- Changes in Rest-Activity Rhythms in Adolescents as They Age: Associations With Brain and Behavioral Changes in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm.eLife · 2025Article
- Dopaminergic Homeostatic Therapy (DHTActa scientific neurology · 2025Article
- Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rest-Activity Rhythms, Their Modulators, and Brain-Clinical Correlates in Opioid Use Disorder.JAMA network open · 2025Article
- Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.Clocks & sleep · 2024Review
- Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study.medRxiv : the preprint server for health sciences · 2024Article
- Divergent Acute and Enduring Changes in 50-kHz Ultrasonic Vocalizations in Rats Repeatedly Treated With Amphetamine and Dopaminergic Antagonists: New Insights on the Role of Dopamine in Calling Behavior.The international journal of neuropsychopharmacology · 2024Article
- Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor.International journal of molecular sciences · 2023Article
- A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice.Psychopharmacology · 2022Article
- Hypothesizing That Pediatric Autoimmune Neuropsychiatric Associated Streptococcal (PANDAS) Causes Rapid Onset of Reward Deficiency Syndrome (RDS) Behaviors and May Require Induction of "Dopamine Homeostasis".Open journal of immunology · 2022Article
- Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUNDCertain components of rest-activity rhythms such as greater eveningness (delayed phase), physical inactivity (blunted amplitude), and shift work (irregularity) are associated with increased risk for drug use. Dopaminergic (DA) signaling has been hypothesized to mediate the associations, though clinical evidence is lacking.METHODSWe examined associations between rhythm components and striatal D1 (D1R) and D2/3 receptor (D2/3R) availability in 32 healthy adults (12 female, 20 male; age 42.40 ± 12.22 years) and its relationship to drug reward. Rest-activity rhythms were assessed by 1-week actigraphy combined with self-reports. [11C]NNC112 and [11C]raclopride positron emission tomography (PET) scans were conducted to measure D1R and D2/3R availability, respectively. Additionally, self-reported drug-rewarding effects of 60 mg oral methylphenidate were assessed.RESULTSWe found that delayed rhythm was associated with higher D1R availability in caudate, which was not attributable to sleep loss or so-called social jet lag, whereas physical inactivity was associated with higher D2/3R availability in nucleus accumbens (NAc). Delayed rest-activity rhythm, higher caudate D1R, and NAc D2/3R availability were associated with greater sensitivity to the rewarding effects of methylphenidate.CONCLUSIONThese findings reveal specific components of rest-activity rhythms associated with striatal D1R, D2/3R availability, and drug-rewarding effects. Personalized interventions that target rest-activity rhythms may help prevent and treat substance use disorders.TRIAL REGISTRATIONClinicalTrials.gov: NCT03190954.FUNDINGNational Institute on Alcohol Abuse and Alcoholism (ZIAAA000550).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.