Trial reportJournal of consulting and clinical psychology2021
A randomized controlled trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) to improve serious mental illness outcomes in a community setting.
Trial report in Journal of consulting and clinical psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05453981 (A Pilot Randomized Controlled Trial on the Efficacy of Transdiagnostic Sleep and Circadian), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Randomized Controlled Trial on the Efficacy of Transdiagnostic Sleep and Circadian (TranS-C) Intervention on Anxiety Symptoms
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Transdiagnostic effects of combined sleep-circadian interventions on depressive symptoms and sleep outcomes in adults with mental disorders: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Objective and subjective measurement of sleep in people who use substances: Emerging evidence and recommendations from a systematic review.Journal of sleep research · 2025Pooled it
- Sleep diary-derived parameters and sleep measures mediate the efficacy of transdiagnostic sleep and circadian intervention for depression.Psychological medicine · 2026Trial
- Patient outcomes and session dose in a randomized controlled trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction: Influential factors and methodological considerations.Behaviour research and therapy · 2026Trial
- Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Outpatients With Sleep Problems and Depression, Attention Deficit Disorder, or Bipolar Disorder: A Randomised Controlled Trial.Journal of sleep research · 2026Trial
- Let's kick that habit: An experiment of five habit-change strategies on habits and symptoms among adults with sleep problems.Journal of behavior therapy and experimental psychiatry · 2025Trial
- A randomized trial of adapted versus standard versions the transdiagnostic intervention for sleep and circadian dysfunction (TSC) implemented via facilitation and delivered by community mental health providers using train-the-trainer.Implementation science : IS · 2025Trial
- Effectiveness of a cognitive-behavioral sleep hygiene intervention for adolescents with ADHD: a randomized controlled trial.European child & adolescent psychiatry · 2025Trial
- An Examination of Training Quality and Provider Outcomes Across Two Generations of Train-the-Trainer.Administration and policy in mental health · 2025Trial
- A randomized trial of adapted versus standard versions of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction implemented via facilitation and delivered by community mental health providers: improving the "fit" of psychological treatments by adapting to context.Implementation science : IS · 2025Trial
- Efficacy of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for Depression Symptoms and Sleep-Wake Disruption in Older and Younger Adults: Secondary Age-Stratified Analysis of a Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Trial
- Outcomes From the Transdiagnostic Sleep and Circadian Intervention (TranS-C) for Midlife and Older Adults With Serious Mental Illness and Sleep and Circadian Dysfunction.Behavior therapy · 2022Trial
- Outcomes of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) in a community setting: Unpacking comorbidity.Behaviour research and therapy · 2021Trial
- A Pilot Trial for Midlife and Older Adults: Sleep and Circadian Treatment Plus Memory Support and Boosters.Clinical gerontologistTrial
- Improving access to help with poor sleep across youth mental health services: Interim implementation and clinical outcomes.The British journal of clinical psychology · 2026Article
- Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sleep and circadian health in the UK Biobank: report on the 2023 sleep questionnaire enhancement.Sleep · 2026Article
- Article
- A primer on sleep neuroscience for psychiatry.NPP - digital psychiatry and neuroscience · 2026Review
- Insomnia symptoms, sleep duration, and risk of falls in older adult women: findings from the Study of Women's Health Across the Nation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine if the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves functional impairment, psychiatric symptoms, and sleep and circadian functioning.
methodAdults diagnosed with serious mental illness (SMI) and sleep and circadian dysfunction (N = 121) were randomly allocated to TranS-C plus usual care (TranS-C + UC; n = 61; 8 individual weekly sessions) or 6 months of Usual Care followed by Delayed Treatment with TranS-C (UC-DT; n = 60). Schizophrenia (45%) and anxiety disorders (47%) were common. Blind assessments were conducted pre-treatment, post-treatment, and 6 months later (6FU). The latter two were the post-randomization points of interest. The location was Alameda County Behavioral Health Care Services (ACBHCS), a Community Mental Health Center (CMHC) in California.
resultsFor the primary outcomes, relative to UC-DT, TranS-C + UC was associated with reduction in functional impairment (b = -3.18, p = 0.025, d = -0.58), general psychiatric symptoms (b = -5.88, p = 0.001, d = -0.64), sleep disturbance (b = -5.55, p < .0001, d = -0.96), and sleep-related impairment (b = -9.14, p < .0001, d = -0.81) from pre-treatment to post-treatment. These effects were maintained to 6-month follow-up (6FU; d = -0.42 to -0.82), except functional impairment (d = -0.37). For the secondary outcomes, relative to UC-DT, TranS-C + UC was associated with improvement in sleep efficiency and on the Sleep Health Composite score from pre-treatment to 6FU. TranS-C + UC was also associated with reduced total wake time and wake time variability from pre-treatment to post-treatment, as well as reduced hallucinations and delusions, bedtime variability, and actigraphy measured waking activity count variability from pre-treatment to 6FU.
conclusionsA novel transdiagnostic treatment, delivered within a CMHC setting, improves selected measures of functioning, symptoms of comorbid disorders, and sleep and circadian outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.