Evidence map›Paper›PMID 34264688›Full record

ArticleBehavioral neuroscience2021

Optogenetic stimulation of the basolateral amygdala accelerates acquisition of object-context associations.

Lauren E DiFazio, David S Reis, Joseph R Manns

Open access · hybridAbstract read
In one paragraph

Article in Behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lauren E DiFazioDepartment of Psychology, Emory University.ORCID 0000-0003-0520-2536
David S ReisDepartment of Psychology, Emory University.
Joseph R MannsDepartment of Psychology, Emory University.
Emory University · US

Funding

Amygdala-mediated enhancement of the hippocampal memory systemR01MH100318 · NIMH · EMORY UNIVERSITY · PI MANNS, JOSEPH R · 2015 to 2019
$1.9M
NIH HHSNIMH NIH HHS R01 MH100318
6 · The paper itself

Abstract

The basolateral complex of the amygdala (BLA) is capable of modulating memory and is thought to do so via projections to regions such as the hippocampus. The present study used optogenetic stimulation of glutamatergic projection neurons in the BLA as rats learned object-context associations during a well-studied hippocampus-dependent memory task. Relative to a control condition, optogenetic BLA stimulation resulted in the accelerated acquisition of when stimulation was delivered following correct choices but not when it was delivered during the intertrial interval. These results extend prior examples of amygdala-mediated memory enhancement to a canonical example of hippocampus-dependent memory and provide an opportunity for future dissection of amygdalar modulation of object-context associative memory. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

Basolateral Nuclear ComplexAmygdalaAnimalsHippocampusMemoryOptogeneticsRats

Identifiers

PMID34264688
PMCPMC8288479
OpenAlexW3181260524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.