Evidence map›Paper›PMID 34264420›Full record

ReviewInsights into imaging2021

A pragmatic evidence-based approach to post-mortem perinatal imaging.

Susan C Shelmerdine, J Ciaran Hutchinson, Celine Lewis, Ian C Simcock, Thivya Sekar, Neil J Sebire, Owen J Arthurs

Abstract readReview
In one paragraph

Review in Insights into imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Post-mortem perinatal imaging: what is the evidence?The British journal of radiology · 2023
    Review
  14. Article
  15. Review
  16. Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susan C ShelmerdineGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK. susan.shelmerdine@gosh.nhs.uk.ORCID http://orcid.org/0000-0001-6642-9967
J Ciaran HutchinsonGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Celine LewisPopulation, Policy and Practice Department, UCL GOS Institute of Child Health, London, UK.ORCID https://orcid.org/0000-0001-7169-1521
Ian C SimcockGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Thivya SekarGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Neil J SebireGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Owen J ArthursGreat Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.ORCID http://orcid.org/0000-0003-1213-3516

Funding

Medical Research Council MR/R002118/1National Institute for Health Research ICA-CDRF-2017-03-53National Institute for Health Research NIHR-300099National Institute for Health Research NIHR-CDF-2017-10-037
6 · The paper itself

Abstract

Post-mortem imaging has a high acceptance rate amongst parents and healthcare professionals as a non-invasive method for investigating perinatal deaths. Previously viewed as a 'niche' subspecialty, it is becoming increasingly requested, with general radiologists now more frequently asked to oversee and advise on appropriate imaging protocols. Much of the current literature to date has focussed on diagnostic accuracy and clinical experiences of individual centres and their imaging techniques (e.g. post-mortem CT, MRI, ultrasound and micro-CT), and pragmatic, evidence-based guidance for how to approach such referrals in real-world practice is lacking. In this review, we summarise the latest research and provide an approach and flowchart to aid decision-making for perinatal post-mortem imaging. We highlight key aspects of the maternal and antenatal history that radiologists should consider when protocolling studies (e.g. antenatal imaging findings and history), and emphasise important factors that could impact the diagnostic quality of post-mortem imaging examinations (e.g. post-mortem weight and time interval). Considerations regarding when ancillary post-mortem image-guided biopsy tests are beneficial are also addressed, and we provide key references for imaging protocols for a variety of cross-sectional imaging modalities.

Indexed as

AutopsyDiagnostic imagingFoetusPregnancy lossRadiology

Identifiers

PMID34264420
PMCPMC8282801

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.