ArticleJournal, genetic engineering & biotechnology2021
Isolation and characterization of marine sponge-associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities.
Article in Journal, genetic engineering & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Antimicrobial activity of some bacteria isolated from marine sponge in Neom region, Saudi Arabia.BMC microbiology · 2025Article
- In-vitro and bioinformatic studies of bioactive compounds from Oceanimonas sp. JM-AZM31 and Lysinibacillus fusiformis JM-AZM37 of sponge-associated marine bacteria from a mangrove habitat in Southeast Sulawesi.Journal, genetic engineering & biotechnology · 2025Article
- Antimicrobial Metabolites Isolated from Some Marine Bacteria Associated withMicroorganisms · 2025Article
- Exploring the mechanisms and mode of action of bioactive compounds from marine Streptomyces albidoflavus against breast carcinoma cells.BMC biotechnology · 2025Article
- Investigation of anti-microbial and cytotoxic potential of Streptomyces werraensis GRS9 derived from the sediments of river Ganga.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Bioactive Fraction of Streptomyces thinghirensis MSA1 Effectively Inhibits Biofilm Forming Clinically Significant AMR Pathogens.Current microbiology · 2025Article
- Optimization and characterization of bioactive secondary metabolites from Streptomyces sp CMSTAAHL-4 isolated from mangrove sediment.BMC microbiology · 2025Article
- Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023).Natural products and bioprospecting · 2025Review
- Actinomycetes: A Source of Anticancer Metabolites.Current medicinal chemistry · 2025Review
- Microbiome profiling and Actinomycetes isolation from tropical marine sponges.AIMS microbiology · 2025Article
- Bioprospecting secondary metabolites with antimicrobial properties from soil bacteria in high-temperature ecosystems.Microbial cell factories · 2024Article
- Evaluation of antibacterial and anticancer properties of secondary metabolites isolated from soil Bacillus spp focusing on two strains of Bacillus licheniformis and Bacillus siamensis.BMC molecular and cell biology · 2024Article
- Bioactive compound from marine seagrass Streptomyces argenteolus TMA13: combatting fish pathogens with time-kill kinetics and live-dead cell imaging.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Alpha-sitosterol: a new antiviral agent produced by Streptomyces misakiensis and its potential activity against Newcastle disease virus.BMC veterinary research · 2024Article
- Article
- Isolation, Identification, and Antibacterial Properties of Prodigiosin, a Bioactive Product Produced by a NewAntibiotics (Basel, Switzerland) · 2023Article
- Unveiling the Pharmacological Significance of MarineMetabolites · 2023Article
- Antioxidant and chemoprotective potential of Streptomyces levis strain isolated from human gut.AMB Express · 2023Article
- Study of marine microorganism metabolites: new resources for bioactive natural products.Frontiers in microbiology · 2023Review
- Recent Progress in Antioxidant Active Substances from Marine Biota.Antioxidants (Basel, Switzerland) · 2022Review
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Abstract
backgroundActinomycetes associated with marine sponge represent a promising source of bioactive compounds. Herein, we report the isolation, identification, and bioactivity evaluation of Streptomyces sp. NMF6 associated with the marine sponge Diacarnus ardoukobae.
resultsResults showed that the strain belonged to the genus Streptomyces, and it was designated as Streptomyces sp. NMF6 with the GenBank accession number MW015111. Ethyl acetate (EtOAc) extract of the strain NMF6 demonstrated a promising antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Vibrio damsela, and Candida albicans and a strong antioxidant activity, which were confirmed by DPPH, ferric-reducing power, and phosphomolybdenum assays; results are expressed as ascorbic acid equivalents. NMF6 extract also demonstrated cytotoxicity against breast cancer cell line (MCF-7), hepatocellular carcinoma cell line (Hep-G2), and human colon carcinoma cell line (HCT-116); the selectivity index values were < 2. The extract showed promising antiviral activity against HSV-1, CoxB4, and hepatitis A viruses at concentrations that were nontoxic to the host cells, with the selectivity index values being 13.25, 9.42, and 8.25, respectively. GC-MS analysis of the extract showed the presence of 20 compounds, with bis(2-ethylhexyl) phthalate being the major component (48%).
conclusionsOur study indicates that the marine sponge-associated Streptomyces sp. NMF6 strain is a potential source of bioactive compounds that could be developed into therapeutic agents.
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