Evidence map›Paper›PMID 34264148›Full record

SynthesisLupus2021

Cognitive impairment in systemic lupus erythematosus is negatively related to social role participation and quality of life: A systematic review.

Sierra Mendelsohn, Lina Khoja, Sofia Alfred, Jennifer He, Melanie Anderson, Denise DuBois, Zahi Touma, Lisa Engel

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Lupus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

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  17. Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Sierra MendelsohnSchool of Medicine, University College Dublin, Dublin, Ireland.
Lina KhojaDepartment of Occupational Science & Occupational Therapy, University of Toronto, Toronto, Ontario, Canada.
Sofia AlfredDepartment of Occupational Science & Occupational Therapy, University of Toronto, Toronto, Ontario, Canada.
Jennifer HeDepartment of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
Melanie AndersonLibrary and Information Services, University Health Network, Toronto, Ontario, Canada.
Denise DuBoisSchool of Rehabilitation Therapy, Canadian Institute for Military and Veterans Health Research, Queen's University, Kingston, Ontario, Canada.
Zahi ToumaCentre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-5177-2076
Lisa EngelDepartment of Occupational Therapy, College of Rehabilitation Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
University of Toronto · CAQueen's University · CAUniversity College Dublin · IEUniversity Health Network · CAUniversity of Manitoba · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAt least 38% of patients with Systemic Lupus Erythematosus (SLE) experience cognitive impairment (CI). Patients report CI impacts their health-related quality of life (HRQoL) and social role participation.

objectivesTo synthesize and critically appraise the quantitative literature on the relationship of CI to HRQoL and social role participation in individuals with SLE.

methodsSix electronic databases were searched in December 2018 and June 2020 by an information specialist. Two reviewers independently completed all screening phases and data extraction; a third reviewer resolved disagreements. The Mixed Methods Appraisal Tool was used to critically appraise the quality of included studies. Data has been synthesized and analyzed descriptively to present evidence on the relationship of CI to HRQoL and social role participation.

resultsA total of 7182 references were identified and screened, with 14 articles included. Four of the included articles investigated the relationship between CI and HRQoL and all identified a negative relationship. Ten of the 14 studies investigated CI and social role participation, eight identified a negative relationship. There was heterogeneity of measures used between studies to examine CI, HRQoL, and social role participation. As such, results were interpreted descriptively and could not be pooled for meta-analysis.

conclusionThe presence of CI is negatively related to HRQoL and social role participation in patients with SLE. Healthcare professionals should be aware of this relationship so that it can be addressed in clinical practice. Further research, using consistent methods of quantifying CI, HRQoL and social role participation, is needed to enable data pooling.

Indexed as

Cognitive DysfunctionLupus Erythematosus, SystemicHumansQuality of Lifecognitionhealth-related quality of lifehealth statusquality of lifesocial role participationSystemic lupus erythematosus

Identifiers

PMID34264148
PMCPMC8489690
OpenAlexW3180917252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.