ArticleJournal of the American Chemical Society2021
Chiral Bifunctional Phosphine Ligand-Enabled Cooperative Cu Catalysis: Formation of Chiral α,β-Butenolides via Highly Enantioselective γ-Protonation.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Recent trends of organic synthesis through cobalt metal-based catalysis: a review.RSC advances · 2026Review
- Asymmetric Decarboxylative Protonation and Deuteration of Cyanoacetic Acids Using an Organometallic Proton Shuttle.Journal of the American Chemical Society · 2026Article
- Copper-catalyzed enantioselective synthesis of γ-butenolides via radical diversification of allenoic acid.Nature communications · 2025Article
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4 authors.
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Abstract
α,β-Butenolides with ≥96% enantiomeric excess are synthesized from β,γ-butenolides via a novel Cu(I)-ligand cooperative catalysis. The reaction is enabled by a chiral biphenyl-2-ylphosphine ligand featuring a remote tertiary amino group. Density functional theory studies support the cooperation between the metal center and the ligand basic amino group during the initial soft deprotonation and the key asymmetric γ-protonation. Remarkably, other coinage metals, that is, Ag and Au, can readily assume the same role as Cu in this asymmetric isomerization chemistry.
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