ArticleJournal of cachexia, sarcopenia and muscle2021
Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants.
Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The correlation between sarcopenia and osteoporosis in the elderly: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Efficacy and safety of odanacatib for osteoporosis treatment: a systematic review and meta-analysis.Archives of osteoporosis · 2023Pooled it
- Postinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Deciphering inter-organ communication: The multi-organ-bone axis in osteoporosis and emerging therapeutic strategies.Journal of orthopaedic translation · 2026Review
- Research progress on the molecular mechanism and clinical evidence of glucagon-like peptide-1 receptor agonists in improving sarcopenia.Diabetology & metabolic syndrome · 2026Review
- Association between sarcopenic obesity and kidney stones: evidence from a prospective cohort study on the UK Biobank.BMC public health · 2026Article
- Article
- Candidate proteomic indirect-effect signals linking dementia to probable muscle-bone fragility: a UK Biobank cohort study.Frontiers in medicine · 2026Article
- Exploring the relationship between consumption of ultra-processed foods and osteoporosis risk: a prospective cohort study.European journal of nutrition · 2025Article
- Low relative sit-to-stand power is associated with history of falls and fractures, prospective hospitalization, and all-cause mortality in older adults from the Toledo study for healthy aging.Journal of sport and health science · 2025Article
- Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1.Journal of bone and mineral metabolism · 2025Article
- Bone-muscle interactions.Osteoporosis and sarcopenia · 2025Review
- A Study of the Effects of Oleuropein and Polydatin Association on Muscle and Bone Metabolism.Biomolecules · 2025Article
- Walking pace and its association with osteoporosis and pathological fractures: insights from UK biobank.Frontiers in endocrinology · 2025Article
- A w-ACT model for sarcopenia among community-dwelling older adults based on National Basic Public Health Services: development and validation study.Frontiers in public health · 2025Article
- Sarcopenia associated with increased risk of comorbidities among individuals with chronic kidney disease: insights from a prospective cohort.Frontiers in public health · 2025Article
- Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients.World journal of diabetes · 2024Article
- Comparative study on muscle-tendon stiffness and balance impairment in postmenopausal women: a focus on osteosarcopenia and osteoporosis.Aging clinical and experimental research · 2024Article
- Association of sarcopenia with the long-term risk of atrial fibrillation: A prospective cohort study.Aging cell · 2024Article
- Crosstalk between muscle and bone.Journal of bone and mineral metabolism · 2024Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
Abstract
backgroundSarcopenia often co-occurs with osteoporosis in cross-sectional studies. However, this association has rarely been studied in prospective studies. This study aimed to investigate the association between sarcopenia categories-along with its individual components-and incident osteoporosis in both middle-aged and older men and women from the UK Biobank study.
methodsA total of 168,682 participants (48.8% women, aged 37 to 70 years at baseline) were included in this prospective study. Categories of sarcopenia (pre-sarcopenia and sarcopenia), and its individual components, were defined according to the EWGSOP2 criteria (2019). Associations with incident osteoporosis by sex were investigated using Cox-proportional hazard models adjusted for socio-demographic, lifestyle and health-related factors, and morbidity count. Associations between categories of sarcopenia and incident osteoporosis were also investigated by age-groups and subtype of osteoporosis (with and without pathological fractures).
resultsAfter a median follow-up of 7.4 years, 6296 participants were diagnosed with osteoporosis. When the analyses were adjusted for a range of relevant confounding factors, pre-sarcopenia was associated with 1.3-times higher risk of osteoporosis in men (HR: 1.30 [95% CI: 1.03 to 1.63]) but not in women, and sarcopenia was associated with 1.66-times increased osteoporosis risk in women (HR: 1.66 [95% CI: 1.33 to 2.08]) but not in men compared with people without sarcopenia or pre-sarcopenia. A similar magnitude of associations was found in osteoporosis without pathological fractures but weaker for those with pathological fractures. Within the individual components, low muscle mass (HR
conclusionsOur findings demonstrated that pre-sarcopenic men and sarcopenic women had a higher risk of developing osteoporosis even after adjustment for a large range of potential confounders. Considering that sarcopenia could be prevented, health interventions to improve physical capability may delay or prevent the onset of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.