Evidence map›Paper›PMID 34263977›Full record

ArticleJournal of cellular and molecular medicine2021

NAADP-induced intracellular calcium ion is mediated by the TPCs (two-pore channels) in hypoxia-induced pulmonary arterial hypertension.

Wen Hu, Fei Zhao, Ling Chen, Jiamin Ni, Yongliang Jiang

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. CaBiomedicines · 2025
    Review
  2. Article
  3. Article
  4. Two-pore channels: going with the flows.Biochemical Society transactions · 2022
    Article
  5. Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen HuRespiratory Medicine, Hunan Provincial People's Hospital, Changsha, China.
Fei ZhaoRespiratory Medicine, Hunan Provincial People's Hospital, Changsha, China.
Ling ChenRespiratory Medicine, Hunan Provincial People's Hospital, Changsha, China.
Jiamin NiRespiratory Medicine, Hunan Provincial People's Hospital, Changsha, China.
Yongliang JiangRespiratory Medicine, Hunan Provincial People's Hospital, Changsha, China.ORCID 0000-0003-4323-2584
Hunan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a form of obstructive vascular disease. Chronic hypoxic exposure leads to excessive proliferation of pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. This condition can potentially be aggravated by [Ca

Indexed as

AnimalsCalciumCalcium ChannelsCells, CulturedEndothelial CellsEndothelium, VascularHypertension, PulmonaryHypoxiaMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPRatsRats, WistarTwo-Pore ChannelsCalciumCalcium ChannelsNAADPNADPTpcn1 protein, ratTpcn2 protein, ratTwo-Pore Channels[Ca2+]ipulmonary arterial hypertension (PAH)pulmonary arterial smooth muscle cells (PASMC)pulmonary artery endothelial cells (PAECs)two-pore segment channel (TPC)

Identifiers

PMID34263977
PMCPMC8335677
OpenAlexW3182232188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.