Evidence map›Paper›PMID 34263725›Full record

ArticleeLife2021

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in

Dayana C Farhat, Matthew W Bowler, Guillaume Communie, Dominique Pontier, Lucid Belmudes, Caroline Mas, Charlotte Corrao, Yohann Couté, Alexandre Bougdour, Thierry Lagrange and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  10. SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024
    Article
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  13. Review
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  15. Epitranscriptome profiling of spleen mRNA mFrontiers in immunology · 2022
    Article
  16. Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Dayana C FarhatIAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Matthew W BowlerEuropean Molecular Biology Laboratory, Grenoble, France.ORCID 0000-0003-0465-3351
Guillaume CommunieInstitut Laue-Langevin, Grenoble, France.
Dominique PontierLaboratoire Génome et Développement des Plantes (LGDP), UMR5096, Centre National de la Recherche Scientifique (CNRS), Université de Perpignan via Domitia (UPVD), Perpignan, France.
Lucid BelmudesUniv. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.
Caroline MasIntegrated Structural Biology Grenoble (ISBG) CNRS, CEA, Université Grenoble Alpes, EMBL, Grenoble, France.
Charlotte CorraoIAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Yohann CoutéUniv. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.ORCID 0000-0003-3896-6196
Alexandre BougdourIAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.ORCID 0000-0002-5895-0020
Thierry LagrangeLaboratoire Génome et Développement des Plantes (LGDP), UMR5096, Centre National de la Recherche Scientifique (CNRS), Université de Perpignan via Domitia (UPVD), Perpignan, France.
Mohamed-Ali Hakimi *IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.ORCID 0000-0002-2547-8233
Christopher Swale *IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.ORCID 0000-0002-9739-7774
Centre National de la Recherche Scientifique · FREuropean Molecular Biology Laboratory · FRInstitut Laue-Langevin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correct 3'end processing of mRNAs is one of the regulatory cornerstones of gene expression. In a parasite that must adapt to the regulatory requirements of its multi-host life style, there is a need to adopt additional means to partition the distinct transcriptional signatures of the closely and tandemly arranged stage-specific genes. In this study, we report our findings in

Indexed as

Genes, DevelopmentalPolyadenylationTranscriptomeArabidopsisBinding SitesCleavage And Polyadenylation Specificity FactorGene Expression RegulationHumansMembrane GlycoproteinsMethyltransferasesModels, MolecularNerve Tissue ProteinsReadingRNA, MessengerRNA Splicing FactorsSequence Analysis, RNACleavage And Polyadenylation Specificity FactorCPSF4 protein, humanMembrane GlycoproteinsMethyltransferasesNerve Tissue ProteinsRNA, MessengerRNA Splicing FactorsYTHDC1 protein, humanArabidopsis thalianaepitranscriptomicinfectious diseasemicrobiologyRNA processingToxoplasma gondii

Identifiers

PMID34263725
PMCPMC8313237
OpenAlexW3180489412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.