ArticleArchives of microbiology2021
Antibacterial and cytotoxic potency of thermophilic Streptomyces werraensis MI-S.24-3 isolated from an Egyptian extreme environment.
Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Bioconversion of wheat and bean straw by thermo-alkaliphilic actinomycetes for enhanced polygalacturonase yield: statistical optimization and industrial application.Biodegradation · 2026Article
- Investigation of anti-microbial and cytotoxic potential of Streptomyces werraensis GRS9 derived from the sediments of river Ganga.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Characteristics and kinetics of thermophilic actinomycetes' amylase production on agro-wastes and its application for ethanol fermentation.World journal of microbiology & biotechnology · 2024Article
- Biodegradation and antimicrobial capability-induced heavy metal resistance of the marine-derived actinomycetes Nocardia harenae JJB5 and Amycolatopsis marina JJB11.World journal of microbiology & biotechnology · 2024Article
- Article
- Anti-Staphylococcal, Anti-Candida, and Free-Radical Scavenging Potential of Soil Fungal Metabolites: A Study Supported by Phenolic Characterization and Molecular Docking Analysis.Current issues in molecular biology · 2023Article
- Article
- Antagonistic Potentiality of Actinomycete-Derived Extract with Anti-Biofilm, Antioxidant, and Cytotoxic Capabilities as a Natural Combating Strategy for Multidrug-Resistant ESKAPE Pathogens.Journal of microbiology and biotechnology · 2023Article
- A swamp forest Streptomyces sp. strain KF15 with broad spectrum antifungal activity against chilli pathogens exhibits anticancer activity on HeLa cells.Archives of microbiology · 2022Article
- In Vitro Phytobiological Investigation of Bioactive Secondary Metabolites from theMolecules (Basel, Switzerland) · 2022Article
- Air Ambulance: Antimicrobial Power of Bacterial Volatiles.Antibiotics (Basel, Switzerland) · 2022Review
- Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes.Frontiers in microbiology · 2022Review
- Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The need for novel and active antibiotics specially from actinomycetes is essential due to new and drug-resistant pathogens. In this study, 87 actinomycetes were isolated, and 18 strains among them characterized as thermophilic actinomycetes. Further fractionation and preliminary antibacterial activities indicated that one strain, coded as MI-S.24-3, showed good antibacterial activity. Based on the phenotypic, genomic, phylogenetic, and biochemical analyses, MI-S.24-3 was identified as Streptomyces werraensis. Results demonstrated that the ethyl acetate active fraction showed maximum antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC (12.7 ± 0.1 and 18.3 ± 0.2 mg/mL), and MBC (96.5 ± 1.4 and 91.5 ± 0.7 mg/mL), respectively, with determination of time kill kinetics assay. The active fraction showed moderate-to-weak cytotoxic effects against human lung carcinoma (A549 cells), breast cancer cell line (MCF-7), and human cervical carcinoma (HELA cells) with a IC
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