Evidence map›Paper›PMID 34263260›Full record

ArticleArchives of cancer biology and therapy2021

Exosome to Promote Cancer Progression via Its Bioactive Cargoes.

Austin McMasters, Kelly M McMasters, Hongying Hao

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Archives of cancer biology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Austin McMastersThe Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA.
Kelly M McMastersThe Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA.
Hongying HaoThe Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA.

Funding

The ExCITE Program: Expediting Commercialization, Innovation, Translation, & EntrepreneurshipU01HL127518 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BATES, PAULA J., MILLER, DONALD M. · 2015 to 2017
$3.0M
NHLBI NIH HHS U01 HL127518
6 · The paper itself

Abstract

Exosomes are nanosized, organelle-like membranous vesicles secreted from various cell types, including normal cells and cancer cells. Exosomes contain abundant bioactive molecules, including nucleic acids, lipids, and proteins and dynamically participate in intercellular communications. By shuttling the functional molecules into the recipient cells, exosomes secreted by cancerous cells can alter the cellular environment to favor tumor growth and metastasis. In this review, we focus on exosomes to promote cancer progression via their various bioactive cargoes through different mechanisms/pathways. By recognizing these pathways, we can design efficient therapeutic strategies to control cancer progression.

Indexed as

Cancer progressioncircRNAExosomelncRNAmicroRNA

Identifiers

PMID34263260
PMCPMC8277159

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.